P
Pankaj Vats
Researcher at University of Michigan
Publications - 53
Citations - 8813
Pankaj Vats is an academic researcher from University of Michigan. The author has contributed to research in topics: Cancer & Prostate cancer. The author has an hindex of 23, co-authored 45 publications receiving 6408 citations. Previous affiliations of Pankaj Vats include Bharathidasan University.
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Journal ArticleDOI
Integrative clinical genomics of advanced prostate cancer
Dan R. Robinson,Eliezer M. Van Allen,Eliezer M. Van Allen,Yi-Mi Wu,Nikolaus Schultz,Robert J. Lonigro,Juan Miguel Mosquera,Bruce Montgomery,Mary-Ellen Taplin,Colin C. Pritchard,Gerhardt Attard,Gerhardt Attard,Himisha Beltran,Wassim Abida,Robert K. Bradley,Jake Vinson,Xuhong Cao,Pankaj Vats,Lakshmi P. Kunju,Maha Hussain,Felix Y. Feng,Scott A. Tomlins,Kathleen A. Cooney,David Smith,Christine Brennan,Javed Siddiqui,Rohit Mehra,Yu Chen,Yu Chen,Dana E. Rathkopf,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Stephen B. Solomon,Jeremy C. Durack,Victor E. Reuter,Anuradha Gopalan,Jianjiong Gao,Massimo Loda,Rosina T. Lis,Michaela Bowden,Michaela Bowden,Stephen P. Balk,Glenn C. Gaviola,Carrie Sougnez,Manaswi Gupta,Evan Y. Yu,Elahe A. Mostaghel,Heather H. Cheng,Hyojeong Mulcahy,Lawrence D. True,Stephen R. Plymate,Heidi Dvinge,Roberta Ferraldeschi,Roberta Ferraldeschi,Penny Flohr,Penny Flohr,Susana Miranda,Susana Miranda,Zafeiris Zafeiriou,Zafeiris Zafeiriou,Nina Tunariu,Nina Tunariu,Joaquin Mateo,Joaquin Mateo,Raquel Perez-Lopez,Raquel Perez-Lopez,Francesca Demichelis,Francesca Demichelis,Brian D. Robinson,Marc H. Schiffman,David M. Nanus,Scott T. Tagawa,Alexandros Sigaras,Kenneth Eng,Olivier Elemento,Andrea Sboner,Elisabeth I. Heath,Howard I. Scher,Howard I. Scher,Kenneth J. Pienta,Philip W. Kantoff,Johann S. de Bono,Johann S. de Bono,Mark A. Rubin,Peter S. Nelson,Levi A. Garraway,Levi A. Garraway,Charles L. Sawyers,Arul M. Chinnaiyan +89 more
TL;DR: This cohort study provides clinically actionable information that could impact treatment decisions for affected individuals and identified new genomic alterations in PIK3CA/B, R-spondin, BRAF/RAF1, APC, β-catenin, and ZBTB16/PLZF.
Journal ArticleDOI
Activating ESR1 mutations in hormone-resistant metastatic breast cancer
Dan R. Robinson,Yi-Mi Wu,Pankaj Vats,Fengyun Su,Robert J. Lonigro,Xuhong Cao,Shanker Kalyana-Sundaram,Rui Wang,Yu Ning,Lynda Hodges,Amy Gursky,Javed Siddiqui,Scott A. Tomlins,Sameek Roychowdhury,Kenneth J. Pienta,Scott Y. H. Kim,J. Scott Roberts,James M. Rae,Catherine Van Poznak,Daniel F. Hayes,Rashmi Chugh,Lakshmi P. Kunju,Moshe Talpaz,Anne F. Schott,Arul M. Chinnaiyan +24 more
TL;DR: Five new LBD-localized ESR1 mutations identified here were shown to result in constitutive activity and continued responsiveness to anti-estrogen therapies in vitro, suggesting that activating mutations in E SR1 are a key mechanism in acquired endocrine resistance in breast cancer therapy.
Journal ArticleDOI
Integrative clinical genomics of metastatic cancer
Dan R. Robinson,Yi-Mi Wu,Robert J. Lonigro,Pankaj Vats,Erin F. Cobain,Jessica Everett,Xuhong Cao,Erica Rabban,Chandan Kumar-Sinha,Victoria M. Raymond,Scott M. Schuetze,Ajjai Alva,Javed Siddiqui,Rashmi Chugh,Francis P. Worden,Mark M. Zalupski,Jeffrey W. Innis,Rajen Mody,Scott A. Tomlins,David R. Lucas,Laurence H. Baker,Nithya Ramnath,Ann F. Schott,Daniel F. Hayes,Joseph Vijai,Kenneth Offit,Elena M. Stoffel,J. Scott Roberts,David Smith,Lakshmi P. Kunju,Moshe Talpaz,Marcin Cieślik,Arul M. Chinnaiyan +32 more
TL;DR: The results show that integrative sequence analysis provides a clinically relevant, multi-dimensional view of the complex molecular landscape and microenvironment of metastatic cancers.
Journal ArticleDOI
Identification of Targetable FGFR Gene Fusions in Diverse Cancers
Yi-Mi Wu,Fengyun Su,Shanker Kalyana-Sundaram,Nickolay A. Khazanov,Bushra Ateeq,Xuhong Cao,Robert J. Lonigro,Pankaj Vats,Rui Wang,Su-Fang Lin,Ann Joy Cheng,Lakshmi P. Kunju,Javed Siddiqui,Scott A. Tomlins,Peter Wyngaard,Seth Sadis,Sameek Roychowdhury,Maha Hussain,Felix Y. Feng,Mark M. Zalupski,Moshe Talpaz,Kenneth J. Pienta,Daniel R. Rhodes,Dan R. Robinson,Arul M. Chinnaiyan +24 more
TL;DR: Because of the combinatorial possibilities of FGFR family fusion to a variety of oligomerization partners, clinical sequencing efforts are poised to identify rare, targetable FGFR fusions across diverse cancer types.
Journal ArticleDOI
Host expression of PD-L1 determines efficacy of PD-L1 pathway blockade–mediated tumor regression
Heng Lin,Shuang Wei,Elaine M. Hurt,Michael D. Green,Lili Zhao,Linda Vatan,Wojciech Szeliga,Ronald Herbst,Paul W. Harms,Leslie A. Fecher,Pankaj Vats,Arul M. Chinnaiyan,Christopher D. Lao,Theodore S. Lawrence,Max S. Wicha,Junzo Hamanishi,Masaki Mandai,Ilona Kryczek,Weiping Zou +18 more
TL;DR: PD-L1–expressing dendritic cells and macrophages may mechanistically shape and therapeutically predict clinical efficacy of PD-L 1/PD-1 blockade.