S
Sandeep Karki
Researcher at Chung-Ang University
Publications - 4
Citations - 363
Sandeep Karki is an academic researcher from Chung-Ang University. The author has contributed to research in topics: Pharmacokinetics & Solubility. The author has an hindex of 3, co-authored 4 publications receiving 255 citations.
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Thin films as an emerging platform for drug delivery
TL;DR: The aim of this review is to provide an overview of the critical factors affecting the formulation of thin films, including the physico-chemical properties of polymers and drugs, anatomical and physiological constraints, as well as the characterization methods and quality specifications to circumvent the difficulties associated with formulation design.
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Preclinical Pharmacokinetic Evaluation of β-Lapachone: Characteristics of Oral Bioavailability and First-Pass Metabolism in Rats
Iksoo Kim,Hyeongmin Kim,Jieun Ro,Kanghee Jo,Sandeep Karki,Prakash Khadka,Gyiae Yun,Jaehwi Lee +7 more
TL;DR: It is suggested that the fairly low oral bioavailability of β-lapachone may be resulted from the first-pass metabolic degradation of α- Lapachone in the liver, small and large intestinal tracts and its low aqueous solubility.
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Viscoelastic interactions between polydeoxyribonucleotide and ophthalmic excipients.
Iksoo Kim,Hyeongmin Kim,Kyunghee Park,Sandeep Karki,Prakash Khadka,Kanghee Jo,Seong Yeon Kim,Jieun Ro,Jaehwi Lee +8 more
TL;DR: PDRN was found to interact with ionicexcipients and the interactions were negligible when nonionic materials were examined, which suggests that nonionic excipients are suitable to be formulated with PDRN.
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Solubility enhancement of celecoxib using solidified Tween 80 for the formulation of tablet dosage forms
Suharto Chakma,Prakash Khadka,Kanghee Jo,Hyeongmin Kim,Jieun Ro,Kyunghee Park,Sandeep Karki,Sonia Barua,Jaehwi Lee +8 more
TL;DR: In this paper, the authors used solid surfactants to improve the solubility and dissolution rate of celecoxib using a mixture of liquid surfactant and inorganic carrier.