Prakash Khadka

TL;DR: A review of solid particle technologies available for improving solubility, dissolution, and bioavailability of drugs with poor aqueous solubilities is presented in this article, where the authors highlight the solid particle technology available to improve the bioavailability.

TL;DR: The S-SMEDDS showed a considerably enhanced lymphatic absoprtion of saquinavir in rats compared to the SMEDDS, which would be usefully exploited to enhance the lymphatic absorption of hydrophobic drugs that need to be targeted to the lymphatics system.

TL;DR: It is suggested that the fairly low oral bioavailability of β-lapachone may be resulted from the first-pass metabolic degradation of α- Lapachone in the liver, small and large intestinal tracts and its low aqueous solubility.

TL;DR: RP loaded PMP and PNP are expected to be advantageous for improved anti-wrinkle effects and showed the abilities to constantly release RP and it could be permeated across the model artificial membrane and rat whole skin.

TL;DR: PDRN was found to interact with ionicexcipients and the interactions were negligible when nonionic materials were examined, which suggests that nonionic excipients are suitable to be formulated with PDRN.