S
Sandeep Kunwar
Researcher at University of California, San Francisco
Publications - 104
Citations - 6394
Sandeep Kunwar is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Transsphenoidal surgery & Medicine. The author has an hindex of 38, co-authored 95 publications receiving 5790 citations. Previous affiliations of Sandeep Kunwar include Washington Hospital & University of San Francisco.
Papers
More filters
Journal ArticleDOI
Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration
Nader Sanai,Anthony D. Tramontin,Alfredo Quiñones-Hinojosa,Nicholas M. Barbaro,Nalin Gupta,Sandeep Kunwar,Michael T. Lawton,Michael W. McDermott,Andrew T. Parsa,José Manuel García Verdugo,Mitchel S. Berger,Arturo Alvarez-Buylla +11 more
TL;DR: A ribbon of SVZ astrocytes lining the lateral ventricles of the adult human brain that proliferate in vivo and behave as multipotent progenitor cells in vitro is described.
Journal ArticleDOI
Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
Sandeep Kunwar,Susan M. Chang,Manfred Westphal,Michael A. Vogelbaum,John H. Sampson,Gene H. Barnett,Mark E. Shaffrey,Zvi Ram,Joseph M. Piepmeier,Michael D. Prados,David Croteau,Christoph Pedain,Pamela Leland,Syed R. Husain,Bharat H. Joshi,Raj K. Puri +15 more
TL;DR: This is the first randomized phase III evaluation of an agent administered via CED and the first with an active comparator in GBM patients, and there was no survival difference between CB administered viaCED and GW.
Journal ArticleDOI
Phase I Trial of Adenovirus-Mediated p53 Gene Therapy for Recurrent Glioma: Biological and Clinical Results
Frederick F. Lang,Janet M. Bruner,Gregory N. Fuller,Kenneth Aldape,Michael D. Prados,Susan M. Chang,Mitchel S. Berger,Michael W. McDermott,Sandeep Kunwar,Larry Junck,William Chandler,James A. Zwiebel,Richard Kaplan,W. K. Alfred Yung +13 more
TL;DR: In this article, a phase I clinical trial of p53 gene therapy using an adenovirus vector (Ad-p53, INGN 201) was conducted to obtain molecular information regarding the transfer and distribution of exogenous p53 into gliomas after intratumoral injection.
Journal ArticleDOI
Direct intracerebral delivery of cintredekin besudotox (IL13-PE38QQR) in recurrent malignant glioma: a report by the Cintredekin Besudotox Intraparenchymal Study Group.
Sandeep Kunwar,Michael D. Prados,Susan M. Chang,Mitchel S. Berger,Frederick F. Lang,Joseph M. Piepmeier,John H. Sampson,Zvi Ram,Philip H. Gutin,Robert D. Gibbons,Kenneth Aldape,David Croteau,Jeffrey W. Sherman,Raj K. Puri +13 more
TL;DR: CED is a complex delivery method requiring catheter placement via a second procedure to achieve accurate catheter positioning, better drug distribution, and better outcome, and appears to have a favorable risk-benefit profile.
Journal ArticleDOI
Progress Report of a Phase I Study of the Intracerebral Microinfusion of a Recombinant Chimeric Protein Composed of Transforming Growth Factor (TGF)-α and a Mutated form of the Pseudomonas Exotoxin Termed PE-38 (TP-38) for the Treatment of Malignant Brain Tumors
John Sampson,Gamal Akabani,Gary E. Archer,Darell D. Bigner,Mitchel S. Berger,Allan H. Friedman,Henry S. Friedman,James E. Herndon,Sandeep Kunwar,Steve Marcus,Roger E. McLendon,Alison Paolino,Kara Penne,James M. Provenzale,Jennifer A. Quinn,David A. Reardon,Jeremy N. Rich,Timothy T. Stenzel,Sandra Tourt-Uhlig,Carol J. Wikstrand,Terence Z. Wong,Roger L. Williams,Fan Yuan,Michael R. Zalutsky,Ira Pastan +24 more
TL;DR: The primary objective of this study was to define the MTD and dose limiting toxicity of TP-38 delivered by convection-enhanced delivery in patients with recurrent malignant brain tumors and one patient developed Grade IV fatigue at the 100ng/mL dose.