M
Mark E. Shaffrey
Researcher at University of Virginia Health System
Publications - 181
Citations - 6334
Mark E. Shaffrey is an academic researcher from University of Virginia Health System. The author has contributed to research in topics: Medicine & Oswestry Disability Index. The author has an hindex of 38, co-authored 158 publications receiving 5486 citations. Previous affiliations of Mark E. Shaffrey include University of Virginia & University of Louisville.
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Journal ArticleDOI
Decompressive bifrontal craniectomy in the treatment of severe refractory posttraumatic cerebral edema.
Richard S. Polin,Mark E. Shaffrey,Christopher A. Bogaev,Nancy Tisdale,Teresa P. Germanson,Ben Bocchicchio,John A. Jane +6 more
TL;DR: Decompressive bifrontal craniectomy provides a statistical advantage over medical treatment of intractable post traumatic cerebral hypertension and should be considered in the management of malignant posttraumatic cerebral swelling.
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Imaging Tumor Angiogenesis With Contrast Ultrasound and Microbubbles Targeted to αvβ3
Dilantha B. Ellegala,Howard Leong-Poi,Joan E. Carpenter,Alexander L. Klibanov,Sanjiv Kaul,Mark E. Shaffrey,Jiri Sklenar,Jonathan R. Lindner +7 more
TL;DR: CEU with microbubbles targeted to &agr;v&bgr;3 can noninvasively detect early tumor angiogenesis and, when coupled with changes in blood volume and velocity, may provide insights into the biology of tumor Angiogenesis.
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Phase III randomized trial of CED of IL13-PE38QQR vs Gliadel wafers for recurrent glioblastoma.
Sandeep Kunwar,Susan M. Chang,Manfred Westphal,Michael A. Vogelbaum,John H. Sampson,Gene H. Barnett,Mark E. Shaffrey,Zvi Ram,Joseph M. Piepmeier,Michael D. Prados,David Croteau,Christoph Pedain,Pamela Leland,Syed R. Husain,Bharat H. Joshi,Raj K. Puri +15 more
TL;DR: This is the first randomized phase III evaluation of an agent administered via CED and the first with an active comparator in GBM patients, and there was no survival difference between CB administered viaCED and GW.
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Poor drug distribution as a possible explanation for the results of the PRECISE trial.
John H. Sampson,Gary E. Archer,Christoph Pedain,Eva Wembacher-Schröder,Manfred Westphal,Sandeep Kunwar,Michael A. Vogelbaum,April Coan,James E. Herndon,Raghu Raghavan,Martin Brady,David A. Reardon,Allan H. Friedman,Henry S. Friedman,M. Inmaculada Rodríguez-Ponce,Susan M. Chang,Stephan Mittermeyer,Davi Croteau,Raj K. Puri,James M. Markert,Michael D. Prados,Thomas C. Chen,Adam N. Mamelak,Timothy F. Cloughesy,John S. Yu,Kevin O. Lillehei,Joseph M. Piepmeier,Edward Pan,Frank D. Vrionis,H. Lee Moffitt,Jeffrey J. Olson,James P. Chandler,Nina Paleologos,Richard W. Byrne,Maciej S. Lesniak,Jon D. Weingart,Peter McL. Black,Tom Mikkelsen,Joon H. Uhm,Richard D. Bucholz,Lauren E. Abrey,Theodore H. Schwartz,Jeffrey N. Bruce,Anthony L. Asher,Stephen B. Tatter,Gene Barnett,Antonio E. Chiocca,Johnny B. Delashaw,Kevin Judy,Sunil J. Patel,Bruce Frankel,Frederick F. Lang,Pamela New,Karen Fink,Randy L. Jensen,Mark E. Shaffrey,Lynne P. Taylor,Warren Boling,Behnam Badie,Abhijit Guha,Vivek Mehta,Mark G. Hamilton,David D. Eisenstat,Farhad Pirouzmand,David R. Macdonald,Rolando F. Del Maestro,Daryl R. Fourney,Maximilian Mehdorn,Roland Goldbrunner,Gabriele Schackert,Andreas Unterberg,Zvi Ram,Zvi R. Cohen,Zvi H. Rappaport,Jan Jacob Mooij,John G. Wolbers,Peter C. Warnke,Varnavas Papanastassiou +77 more
TL;DR: Routine use of software algorithms and alternative catheter designs and infusion parameters may improve the efficacy of drugs delivered by CED, which may be severely constrained by ineffective delivery in many patients.
Journal ArticleDOI
Neurosurgical Applications of Fibrin Glue: Augmentation of Dural Closure in 134 Patients
TL;DR: In a wide variety of neurosurgical procedures performed on 134 patients over a 3-year period, fibrin glue has been applied as an adjunct to dural closure with overall success at preventing cerebrospinal fluid leakage.