K
Kenneth Aldape
Researcher at Princess Margaret Cancer Centre
Publications - 401
Citations - 43492
Kenneth Aldape is an academic researcher from Princess Margaret Cancer Centre. The author has contributed to research in topics: Glioma & Cancer. The author has an hindex of 97, co-authored 401 publications receiving 36906 citations. Previous affiliations of Kenneth Aldape include University of Texas at Austin & University of Texas MD Anderson Cancer Center.
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Journal Article
The Cancer Genome Atlas Pan-Cancer analysis project
Kyle Chang,Chad J Creighton,Caleb F. Davis,Lawrence A. Donehower,Jennifer Drummond,David A. Wheeler,Adrian Ally,Miruna Balasundaram,Inanc Birol,Yaron S.N. Butterfield,Andy Chu,Eric Chuah,Hye Jung E. Chun,Noreen Dhalla,Ranabir Guin,Martin Hirst,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Andrew J. Mungall,A. Gordon Robertson,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Richard Varhol,Rameen Beroukhim,Ami S. Bhatt,Angela N. Brooks,Andrew D. Cherniack,Samuel S. Freeman,Stacey Gabriel,Elena Helman,Joonil Jung,Matthew Meyerson,Akinyemi I. Ojesina,Chandra Sekhar Pedamallu,Gordon Saksena,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Eric S. Lander,Christopher A. Bristow,Angela Hadjipanayis,Psalm Haseley,Raju Kucherlapati,Semin Lee,Eunjung Lee,Lovelace J. Luquette,Harshad S. Mahadeshwar,Angeliki Pantazi,Michael Parfenov,Peter J. Park,Alexei Protopopov,Xiaojia Ren,Netty Santoso,Jonathan G. Seidman,Sahil Seth,Xingzhi Song,Jiabin Tang,Ruibin Xi,Andrew Wei Xu,Lixing Yang,Dong Zeng,J. Todd Auman,Saianand Balu,Elizabeth Buda,Cheng Fan,Katherine A. Hoadley,Corbin D. Jones,Shaowu Meng,Piotr A. Mieczkowski,Joel S. Parker,Charles M. Perou,Jeffrey Roach,Yan Shi,Grace O. Silva,Donghui Tan,Umadevi Veluvolu,Scot Waring,Matthew D. Wilkerson,Junyuan Wu,Wei Zhao,Tom Bodenheimer,D. Neil Hayes,Alan P. Hoyle,Stuart R. Jeffreys,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Stephen B. Baylin,Benjamin P. Berman,Moiz S. Bootwalla,Ludmila Danilova,James G. Herman,Toshinori Hinoue,Peter W. Laird,Suhn K. Rhie,Hui Shen,Timothy J. Triche,Daniel J. Weisenberger,Scott L. Carter,Kristian Cibulskis,Lynda Chin,Jianhua Zhang,Gad Getz,Carrie Sougnez,Min Wang,Huyen Dinh,Harshavardhan Doddapaneni,Richard A. Gibbs,Preethi H. Gunaratne,Yi Han,Divya Kalra,Christie Kovar,Lora Lewis,Margaret Morgan,Donna Morton,Donna M. Muzny,Jeffrey G. Reid,Liu Xi,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Jaegil Kim,Michael S. Lawrence,Pei Lin,Yingchun Liu,Michael S. Noble,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Chip Stewart,Brady Bernard,Ryan Bressler,Andrea Eakin,Lisa Iype,Theo A. Knijnenburg,Roger Kramer,Richard Kreisberg,Kalle Leinonen,Jake Lin,Yuexin Liu,Michael W. Miller,Sheila Reynolds,Hector Rovira,Ilya Shmulevich,Vesteinn Thorsson,Da Yang,Wei Zhang,Samirkumar B. Amin,Chang-Jiun Wu,Chia Chin Wu,Rehan Akbani,Kenneth Aldape,Keith A. Baggerly,Bradley M. Broom,Tod D. Casasent,James Cleland,Chad J. Creighton,Deepti Dodda,Mary E. Edgerton,Leng Han,Shelley M. Herbrich,Zhenlin Ju,Hoon Kim,Seth P. Lerner,Jun Li,Han Liang,Wen-Bin Liu,Philip L. Lorenzi,Yiling Lu,James M. Melott,Gordon B. Mills,Lam Nhat Nguyen,Xiaoping Su,Roeland Verhaak,Wenyi Wang,John N. Weinstein,Andrew Wong,Yang Yang,Jun Yao,Rong Yao,Kosuke Yoshihara,Yuan Yuan,Alfred K Yung,Nianxiang Zhang,Siyuan Zheng,Michael T. Ryan,David W. Kane,B. Arman Aksoy,Giovanni Ciriello,Gideon Dresdner,Jianjiong Gao,Benjamin Gross,Anders Jacobsen,André Kahles,Marc Ladanyi,William H. Lee,Kjong-Van Lehmann,Martin L. Miller,Ricardo Ramirez,Gunnar Rätsch,Boris Reva,Chris Sander,Nikolaus Schultz,Yasin Senbabaoglu,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Yichao Sun,Barry S. Taylor,Nils Weinhold,Suzanne S. Fei,Paul T. Spellman,Christopher C. Benz,Daniel E. Carlin,Melisssa Cline,Brian Craft,Kyle Ellrott,Mary Goldman,David Haussler,Singer Ma,Sam Ng,Evan O. Paull,Amie Radenbaugh,Sofie R. Salama,Artem Sokolov,Joshua M. Stuart,Teresa Swatloski,Vladislav Uzunangelov,Peter Waltman,Christina Yau,Jing Zhu,Stanley R. Hamilton,Scott Abbott,Rachel Abbott,Nathan D. Dees,Kim D. Delehaunty,Li Ding,David J. Dooling,James M. Eldred,Catrina Fronick,Robert S. Fulton,Lucinda Fulton,Joelle Kalicki-Veizer,Krishna-Latha Kanchi,Cyriac Kandoth,Daniel C. Koboldt,David E. Larson,Timothy J. Ley,Ling Lin,Charles Lu,Vincent Magrini,Elaine R. Mardis,Michael D. McLellan,Joshua F. McMichael,Christopher A. Miller,Michelle O'Laughlin,Craig Pohl,Heather Schmidt,Scott M. Smith,Jason Walker,John W. Wallis,Michael C. Wendl,Richard K. Wilson,Todd Wylie,Qunyuan Zhang,Robert A. Burton,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Yunhu Wan,Douglas A. Levine,Aaron D. Black,Jay Bowen,Jessica Frick,Julie M. Gastier-Foster,Hollie A. Harper,Carmen Helsel,Kristen M. Leraas,Tara M. Lichtenberg,Cynthia McAllister,Nilsa C. Ramirez,Samantha Sharpe,Lisa Wise,Erik Zmuda,Stephen J. Chanock,Tanja Davidsen,John A. Demchok,Greg Eley,Ina Felau,Brad Ozenberger,Margi Sheth,Heidi J. Sofia,Louis M. Staudt,Roy Tarnuzzer,Zhining Wang,Liming Yang,Jiashan Zhang,Larsson Omberg,Adam A. Margolin,Benjamin J. Raphael,Fabio Vandin,Hsin-Ta Wu,Mark D.M. Leiserson,Stephen C. Benz,Charles J. Vaske,Houtan Noushmehr,Denise M. Wolf,Laura van 't Veer,Eric A. Collisson,Dimitris Anastassiou,Tai-Hsien Ou Yang,Nuria Lopez-Bigas,Abel Gonzalez-Perez,David Tamborero,Zheng Xia,Wei Li,Dong-Yeon Cho,Teresa M. Przytycka,Mark P. Hamilton,Sean E. McGuire,Sven Nelander,Patrik Johansson,Rebecka Jörnsten,Teresia Kling,Jose Miguel Sanchez,Kenna R. Mills Shaw +337 more
TL;DR: The Cancer Genome Atlas (TCGA) Research Network has profiled and analyzed large numbers of human tumors to discover molecular aberrations at the DNA, RNA, protein and epigenetic levels as mentioned in this paper.
Journal ArticleDOI
Comprehensivemolecular characterization of clear cell renal cell carcinoma
Chad J. Creighton,Margaret Morgan,Preethi H. Gunaratne,Preethi H. Gunaratne,David A. Wheeler,Richard A. Gibbs,Gordon Robertson,Andy Chu,Rameen Beroukhim,Kristian Cibulskis,Sabina Signoretti,Fabio Vandin,Hsin-Ta Wu,Benjamin J. Raphael,Roel G.W. Verhaak,Pheroze Tamboli,Wandaliz Torres-Garcia,Rehan Akbani,John N. Weinstein,Victor E. Reuter,James J. Hsieh,A. Rose Brannon,A. Ari Hakimi,Anders Jacobsen,Giovanni Ciriello,Boris Reva,Christopher J. Ricketts,W. Marston Linehan,Joshua M. Stuart,W. Kimryn Rathmell,Shen Hui,Peter W. Laird,Donna M. Muzny,Caleb F. Davis,Xi Liu,Kyle Chang,Nipun Kakkar,Lisa R. Trevino,Susan M. Benton,Jeffrey G. Reid,Donna Morton,Harsha Doddapaneni,Han Yi,Lora Lewis,Dinh Huyen,Christie Kovar,Yiming Zhu,Jireh Santibanez,Wang Min,Walker Hale,Divya Kalra,Gad Getz,Michael S. Lawrence,Carrie Sougnez,Scott L. Carter,Andrey Sivachenko,Lichtenstein Lee,Chip Stewart,Doug Voet,Sheila Fisher,Stacey Gabriel,Eric S. Lander,Steve Schumacher,Barbara Tabak,Gordon Saksena,Robert C. Onofrio,Andrew D. Cherniack,Jeff Gentry,Kristin G. Ardlie,Matthew Meyerson,Hye Jung E. Chun,Andrew J. Mungall,Payal Sipahimalani,Dominik Stoll,Adrian Ally,Miruna Balasundaram,Yaron S.N. Butterfield,Rebecca Carlsen,Candace Carter,Eric Chuah,Robin J.N. Coope,Noreen Dhalla,Sharon M. Gorski,Ranabir Guin,Carrie Hirst,Martin Hirst,Robert A. Holt,Chandra Lebovitz,Darlene Lee,Haiyan I. Li,Michael Mayo,Richard A. Moore,Erin Pleasance,Patrick Plettner,Jacqueline E. Schein,Arash Shafiei,Jared R. Slobodan,Angela Tam,Nina Thiessen,Richard Varhol,Natasja Wye,Yongjun Zhao,Inanc Birol,Steven J.M. Jones,Marco A. Marra,J. Todd Auman,Donghui Tan,Corbin D. Jones,Katherine A. Hoadley,Piotr A. Mieczkowski,Lisle E. Mose,Stuart R. Jefferys,Michael D. Topal,Christina Liquori,Yidi J. Turman,Shi Yan,Scot Waring,Elizabeth Buda,Jesse Walsh,Junyuan Wu,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Mathew G. Soloway,Saianand Balu,Joel S. Parker,D. Neil Hayes,Charles M. Perou,Raju Kucherlapati,Peter J. Park,Timothy J. Triche,Daniel J. Weisenberger,Phillip H. Lai,Moiz S. Bootwalla,Dennis T. Maglinte,Swapna Mahurkar,Benjamin P. Berman,David Van Den Berg,Leslie Cope,Stephen B. Baylin,Michael S. Noble,Daniel DiCara,Hailei Zhang,Juok Cho,David I. Heiman,Nils Gehlenborg,William Mallard,Lin Pei,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zhou,Jaegil Kim,Lynda Chin,Lynda Chin,Christopher C. Benz,Christina Yau,Sheila Reynolds,Ilya Shmulevich,Rahul Vegesna,Hoon Kim,Zhang Wei,David Cogdell,Eric Jonasch,Zhiyong Ding,Yiling Lu,Nianxiang Zhang,Anna K. Unruh,Tod D. Casasent,Chris Wakefield,Dimitra Tsavachidou,Gordon B. Mills,Jianjiong Gao,Ethan Cerami,Benjamin Gross,B. Arman Aksoy,Rileen Sinha,Nils Weinhold,S. Onur Sumer,Barry S. Taylor,Ronglai Shen,Irina Ostrovnaya,Michael F. Berger,Marc Ladanyi,Chris Sander,Suzanne S. Fei,Andrew J. Stout,Paul T. Spellman,Daniel L. Rubin,Tiffany Ting Liu,Ng Sam,Evan O. Paull,Daniel E. Carlin,Theodore C. Goldstein,Peter Waltman,Kyle Ellrott,Zhu Jing,David Haussler,Weimin Xiao,Candace Shelton,Johanna Gardner,Robert Penny,Mark E. Sherman,David Mallery,Scott Morris,Joseph Paulauskis,Ken Burnett,Troy Shelton,William G. Kaelin,William G. Kaelin,Toni K. Choueiri,Michael B. Atkins,Erin Curley,Satish K. Tickoo,Leigh B. Thorne,Lori Boice,Huang Mei,Jennifer C. Fisher,Cathy D. Vocke,James Peterson,Robert Worrell,Maria J. Merino,Laura S. Schmidt,Laura S. Schmidt,Bogdan Czerniak,Kenneth Aldape,Christopher G. Wood,Jeff Boyd,Jo Ellen Weaver,Mary Iacocca,Nicholas J. Petrelli,Gary Witkin,Jennifer Brown,Christine Czerwinski,Lori Huelsenbeck-Dill,Brenda Rabeno,Jerome Myers,Carl Morrison,Julie Bergsten,John Eckman,Jodi Harr,Christine I. Smith,Kelinda Tucker,Leigh Anne Zach,Wiam Bshara,Carmelo Gaudioso,Rajiv Dhir,Jodi K. Maranchie,Joel B. Nelson,Anil V. Parwani,Cureline Olga Potapova,Konstantin V. Fedosenko,John C. Cheville,R. Houston Thompson,Juan M. Mosquera,Mark A. Rubin,Michael L. Blute,Todd Pihl,Mark A. Jensen,Robert Sfeir,Ari B. Kahn,Anna Chu,Prachi Kothiyal,Eric E. Snyder,Joan Pontius,Brenda Ayala,Mark Backus,Jessica Walton,Julien Baboud,Dominique L. Berton,Matthew C. Nicholls,Deepak Srinivasan,Rohini Raman,Stanley Girshik,Peter A. Kigonya,Shelley Alonso,Rashmi N. Sanbhadti,Sean P. Barletta,David Pot,Margi Sheth,John A. Demchok,Tanja Davidsen,Zhining Wang,Liming Yang,Roy Tarnuzzer,Jiashan Zhang,Greg Eley,Martin L. Ferguson,Kenna R. Mills Shaw,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +291 more
TL;DR: Remodelling cellular metabolism constitutes a recurrent pattern in ccRCC that correlates with tumour stage and severity and offers new views on the opportunities for disease treatment.
Journal ArticleDOI
Comprehensive molecular characterization of urothelial bladder carcinoma
John N. Weinstein,Rehan Akbani,Bradley M. Broom,Wenyi Wang,Roeland Verhaak,David J. McConkey,Seth P. Lerner,Margaret Morgan,Chad J. Creighton,Carolyn L. Smith,Andrew D. Cherniack,Jaegil Kim,Chandra Sekhar Pedamallu,Michael S. Noble,Hikmat Al-Ahmadie,Victor E. Reuter,Jonathan E. Rosenberg,Dean F. Bajorin,Bernard H. Bochner,David B. Solit,Theresa M. Koppie,Brian D. Robinson,Dmitry A. Gordenin,David C. Fargo,Leszek J. Klimczak,Steven A. Roberts,Jessie Au,Peter W. Laird,Toshinori Hinoue,Nikolaus Schultz,Ricardo Ramirez,Donna E. Hansel,Katherine A. Hoadley,William Y. Kim,Jeffrey S. Damrauer,Stephen B. Baylin,Andrew J. Mungall,A. Gordon Robertson,Andy Chu,David J. Kwiatkowski,Carrie Sougnez,Kristian Cibulskis,Lee Lichtenstein,Andrey Sivachenko,Chip Stewart,Michael S. Lawrence,Gad Getz,Eric S. Lander,Stacey B. Gabrie,Lawrence A. Donehower,Scott L. Carter,Gordon Saksena,Steven E. Schumacher,Samuel S. Freeman,Joonil Jung,Ami S. Bhatt,Trevor J. Pugh,Rameen Beroukhim,Matthew Meyerson,Adrian Ally,Miruna Balasundaram,Yaron S.N. Butterfield,Noreen Dhalla,Carrie Hirst,Robert A. Holt,Steven J.M. Jones,Darlene Lee,Haiyan I. Li,Marco A. Marra,Michael Mayo,Richard A. Moore,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Natasja Wye,Reanne Bowlby,Eric Chuah,Ranabir Guin,Hui Shen,Moiz S. Bootwalla,Timothy J. Triche,Phillip H. Lai,David Van Den Berg,Daniel J. Weisenberger,Saianand Balu,Tom Bodenheimer,Alan P. Hoyle,Stuart R. Jefferys,Shaowu Meng,Lisle E. Mose,Janae V. Simons,Mathew G. Soloway,Junyuan Wu,Joel S. Parker,D. Neil Hayes,Jeffrey Roach,Elizabeth Buda,Corbin D. Jones,Piotr A. Mieczkowski,Donghui Tan,Umadevi Veluvolu,Scot Waring,J. Todd Auman,Charles M. Perou,Matthew D. Wilkerson,Netty Santoso,Michael Parfenov,Xiaojia Ren,Angeliki Pantazi,Angela Hadjipanayis,Jonathan G. Seidman,Raju Kucherlapati,Semin Lee,Lixing Yang,Peter J. Park,Andrew Wei Xu,Alexei Protopopov,Jianhua Zhang,Christopher A. Bristow,Harshad S. Mahadeshwar,Sahil Seth,Xingzhi Song,Jiabin Tang,Dong Zeng,Lynda Chin,Lynda Chin,Charles C. Guo,Tod D. Casasent,Wenbin Liu,Zhenlin Ju,Thomas C. Motter,Bo Peng,Michael Ryan,Xiaoping Su,Ji Yeon Yang,Philip L. Lorenzi,Hui Yao,Nianxiang Zhang,Jiexin Zhang,Gordon B. Mills,Juok Cho,Daniel DiCara,Scott Frazer,Nils Gehlenborg,David I. Heiman,Pei Lin,Yingchun Liu,Petar Stojanov,Doug Voet,Hailei Zhang,Lihua Zou,Brady Bernard,Dick Kreisberg,Sheila Reynolds,Hector Rovira,Ilya Shmulevich,Jianjiong Gao,Anders Jacobsen,B. Arman Aksoy,Yevgeniy Antipin,Giovanni Ciriello,Gideon Dresdner,Benjamin Gross,William Lee,Boris Reva,Ronglai Shen,Rileen Sinha,S. Onur Sumer,Nils Weinhold,Marc Ladanyi,Chris Sander,Christopher C. Benz,Daniel E. Carlin,David Haussler,Sam Ng,Evano Paull,Joshua M. Stuart,Jing Zhu,Yuexin Liu,Wei Zhang,Barry S. Taylor,Tara M. Lichtenberg,Erik Zmuda,Thomas Barr,Aaron D. Black,Myra M. George,Benjamin Hanf,Carmen Helsel,Cynthia McAllister,Nilsa C. Ramirez,Nilsa C. Ramirez,Teresa R. Tabler,Stephanie Weaver,Lisa Wise,Jay Bowen,Julie M. Gastier-Foster,Julie M. Gastier-Foster,Weiguo Jian,Sebrina A Tello,Michael Ittman,Patricia Castro,Whitney D. McClenden,Richard A. Gibbs,Charles Saller,Katherine Tarvin,Jennifer DiPiero,Jennifer Owens,Roni J. Bollag,Qiang Li,Paul M. Weinberger,Christine Czerwinski,Lori Huelsenbeck-Dill,Mary Iacocca,Nicholas J. Petrelli,Brenda Rabeno,Pat Swanson,Troy Shelton,Erin Curley,Johanna Gardner,David Mallery,Robert Penny,Nguyen Van Bang,Phan Thi Hanh,Bernard Kohl,Xuan Van Le,Bui Duc Phu,Richard Thorp,Nguyen Viet Tien,Le Quang Vinh,George E. Sandusky,Eric J. Burks,Kimberly R. Christ,Jason R. Gee,Antonia H. Holway,Alireza Moinzadeh,Andrea Sorcini,Travis Sullivan,Ilana Rebecca Garcia-Grossman,Ashley Marie Regazzi,Lori Boice,W.K. Rathmell,Leigh B. Thorne,Sheldon I. Bastacky,Benjamin Davies,Rajiv Dhir,Jeffrey R. Gingrich,Ronald L. Hrebinko,Jodi K. Maranchie,Joel B. Nelson,Anil V. Parwani,Wiam Bshara,Carmelo Gaudioso,Carl Morrison,Vina Alexopoulou,John M. S. Bartlett,Jay Engel,Sugy Kodeeswaran,Tatjana Antic,Peter H. O'Donnell,Norm D. Smith,Gary D. Steinberg,Sophie C. Egea,Carmen Gomez-Fernandez,Lynn M. Herbert,Merce Jorda,Mark S. Soloway,Allison Beaver,Suzie Carter,Payal Kapur,Cheryl M. Lewis,Yair Lotan,Jolanta Bondaruk,Bogdan Czerniak,Eila C. Skinner,Kenneth Aldape,Mark A. Jensen,Ari B. Kahn,Todd Pihl,David Pot,Deepak Srinivasan,Yunhu Wan,Martin L. Ferguson,Jean C. Zenklusen,Tanja Davidsen,John A. Demchok,Kenna R. Mills Shaw,Kenna R. Mills Shaw,Margi Sheth,Roy Tarnuzzer,Zhining Wang,Liming Yang,Carolyn M. Hutter,Bradley A. Ozenberger,Heidi J. Sofia,Greg Eley +296 more
TL;DR: Ch Chromatin regulatory genes were more frequently mutated in urothelial carcinoma than in any other common cancer studied so far, indicating the future possibility of targeted therapy for chromatin abnormalities.
Journal ArticleDOI
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
Roger Stupp,Roger Stupp,Monika E. Hegi,Thierry Gorlia,Sara Erridge,James Perry,Yong-Kil Hong,Kenneth Aldape,Benoit Lhermitte,Torsten Pietsch,Danica Grujicic,Joachim P. Steinbach,Wolfgang Wick,Rafal Tarnawski,Do-Hyun Nam,Peter Hau,Astrid Weyerbrock,Martin J B Taphoorn,Chiung-Chyi Shen,Nalini Rao,László Thurzó,Ulrich Herrlinger,Tejpal Gupta,Rolf-Dieter Kortmann,Krystyna Adamska,Catherine McBain,Alba A. Brandes,Joerg C. Tonn,Oliver Schnell,Thomas Wiegel,Chae-Yong Kim,Louis B. Nabors,David A. Reardon,Martin J. van den Bent,Christine Hicking,Andriy Markivskyy,Martin Picard,Michael Weller +37 more
TL;DR: This multicentre, open-label, phase 3 study investigated the efficacy of cilengitide in patients from 146 study sites in 25 countries and found none of the predefined clinical subgroups showed a benefit.
Journal ArticleDOI
The Somatic Genomic Landscape of Chromophobe Renal Cell Carcinoma
Caleb F. Davis,Christopher J. Ricketts,Min Wang,Lixing Yang,Andrew D. Cherniack,Hui Shen,Christian J. Buhay,Hyojin Kang,Sang Cheol Kim,Catherine C. Fahey,Kathryn E. Hacker,Gyan Bhanot,Dmitry A. Gordenin,Andy Chu,Preethi H. Gunaratne,Preethi H. Gunaratne,Michael Biehl,Sahil Seth,Benny Abraham Kaipparettu,Christopher A. Bristow,Lawrence A. Donehower,Eric Wallen,Angela B. Smith,Satish K. Tickoo,Pheroze Tamboli,Victor E. Reuter,Laura S. Schmidt,James J. Hsieh,James J. Hsieh,Toni K. Choueiri,A. Ari Hakimi,Chad J. Creighton,Margaret Morgan,David A. Wheeler,Richard A. Gibbs,Sabina Signoretti,A. Gordon Robertson,Elizabeth P. Henske,David J. Kwiatkowski,Christopher J. Ricketts,W. Marston Linehan,Michael P. Seiler,W. Kimryn Rathmell,Peter W. Laird,Brian Shuch,Donna M. Muzny,Hsu Chao,Mike Dahdouli,Liu Xi,Nipun Kakkar,Jeffrey G. Reid,Brittany Downs,Jennifer Drummond,Donna Morton,Harsha Doddapaneni,Lora Lewis,Adam C. English,Qingchang Meng,Christie Kovar,Qiaoyan Wang,Walker Hale,Alicia Hawes,Divya Kalra,Kimberly Walker,Bradley A. Murray,Carrie Sougnez,Gordon Saksena,Scott L. Carter,Steven E. Schumacher,Barbara Tabak,Travis I. Zack,Gad Getz,Rameen Beroukhim,Stacey Gabriel,Matthew Meyerson,Adrian Ally,Miruna Balasundaram,Inanc Birol,Denise Brooks,Yaron S.N. Butterfield,Eric Chuah,Amanda Clarke,Noreen Dhalla,Ranabir Guin,Robert A. Holt,Katayoon Kasaian,Darlene Lee,Haiyan I. Li,Emilia L. Lim,Yussanne Ma,Michael Mayo,Richard A. Moore,Andrew J. Mungall,Jacqueline E. Schein,Payal Sipahimalani,Angela Tam,Nina Thiessen,Tina Wong,Steven J.M. Jones,Marco A. Marra,J. Todd Auman,Donghui Tan,Shaowu Meng,Corbin D. Jones,Katherine A. Hoadley,Piotr A. Mieczkowski,Lisle E. Mose,Stuart R. Jefferys,Jeffrey Roach,Umadevi Veluvolu,Matthew D. Wilkerson,Scot Waring,Elizabeth Buda,Junyuan Wu,Tom Bodenheimer,Alan P. Hoyle,Janae V. Simons,Mathew G. Soloway,Saianand Balu,Joel S. Parker,D. Neil Hayes,Charles M. Perou,Daniel J. Weisenberger,Moiz S. Bootwalla,Timothy J. Triche,Phillip H. Lai,David Van Den Berg,Stephen B. Baylin,Fengju Chen,Cristian Coarfa,Michael S. Noble,Daniel DiCara,Hailei Zhang,Juok Cho,David I. Heiman,Nils Gehlenborg,Doug Voet,Pei Lin,Scott Frazer,Petar Stojanov,Yingchun Liu,Lihua Zou,Jaegil Kim,Michael S. Lawrence,Lynda Chin,Alexei Protopopov,Xingzhi Song,Jianhua Zhang,Angeliki Pantazi,Angela Hadjipanayis,Eunjung Lee,Lovelace J. Luquette,Semin Lee,Michael Parfenov,Netty Santoso,Jonathan G. Seidman,Andrew Wei Xu,Raju Kucherlapati,Peter J. Park,Junehawk Lee,Steven A. Roberts,Leszek J. Klimczak,David C. Fargo,Martin Lang,Yoon-La Choi,June Koo Lee,Woong-Yang Park,Wenyi Wang,Yu Fan,Jaeil Ahn,Rehan Akbani,John N. Weinstein,David Haussler,Singer Ma,Amie Radenbaugh,Jingchun Zhul,Tara M. Lichtenberg,Erik Zmuda,Aaron D. Black,Benjamin Hanf,Nilsa C. Ramirez,Lisa Wise,Jay Bowen,Kristen M. Leraas,Tracy M. Hall,Julie M. Gastier-Foster,William G. Kaelin,Leigh B. Thorne,Lori Boice,Mei Huang,Cathy D. Vocke,James Peterson,Robert Worrell,Maria J. Merino,Bogdan Czerniak,Kenneth Aldape,Christopher G. Wood,Paul T. Spellman,Michael B. Atkins,John C. Cheville,R. Houston Thompson,Mark A. Jensen,Todd Pihl,Yunhu Wan,Brenda Ayala,Julien Baboud,Sudhakar Velaga,Jessica Walton,Jia Liu,Sudha Chudamani,Ye Wu,Margi Sheth,Kenna R. Mills Shaw,John A. Demchok,Tanja M. Davidsen,Liming Yang,Zhining Wang,Roy Tarnuzzer,Jiashan Zhang,Greg Eley,Ina Felau,Jean C. Zenklusen,Carolyn M. Hutter,Mark S. Guyer,Bradley A. Ozenberger,Heidi J. Sofia +225 more
TL;DR: Genomic rearrangements lead to recurrent structural breakpoints within TERT promoter region, which correlates with highly elevated TERT expression and manifestation of kataegis, representing a mechanism of TERT upregulation in cancer distinct from previously observed amplifications and point mutations.