S
Sandor Fritsch
Researcher at Baxter International
Publications - 42
Citations - 2269
Sandor Fritsch is an academic researcher from Baxter International. The author has contributed to research in topics: Vaccination & Population. The author has an hindex of 24, co-authored 42 publications receiving 2025 citations. Previous affiliations of Sandor Fritsch include Icahn School of Medicine at Mount Sinai.
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Journal ArticleDOI
Break-through bleeding in relation to predicted factor VIII levels in patients receiving prophylactic treatment for severe hemophilia A
Peter William Collins,Victor Blanchette,Krista Fischer,Sven Björkman,Myungshin Oh,Sandor Fritsch,Phillip Schroth,Gerald Spotts,Jan Astermark,Bruce M. Ewenstein +9 more
TL;DR: It is demonstrated that increasing time with a FVIII below 1 IU dL−1 is associated with increased total bleeds and hemarthroses, and has important implications for the management of patients with severe hemophilia.
Journal ArticleDOI
A Clinical Trial of a Whole-Virus H5N1 Vaccine Derived from Cell Culture
Hartmut J. Ehrlich,Markus Müller,Helen M. L. Oh,Paul A. Tambyah,Christian Joukhadar,Emanuele Montomoli,Dale A. Fisher,Greg Berezuk,Sandor Fritsch,Alexandra Löw-Baselli,Nina Vartian,Roman Bobrovsky,Borislava G. Pavlova,Eva Maria Pöllabauer,Otfried Kistner,P. Noel Barrett +15 more
TL;DR: A two-dose vaccine regimen of either 7.5 microg or 15 microg of hemagglutinin antigen without adjuvant induced neutralizing antibodies against diverse H5N1 virus strains in a high percentage of subjects, suggesting that this may be a useful H5n1 vaccine.
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Population pharmacokinetics of recombinant factor VIII : the relationships of pharmacokinetics to age and body weight
Sven Björkman,Myungshin Oh,Gerald Spotts,Phillip Schroth,Sandor Fritsch,Bruce M. Ewenstein,Kathleen M. Casey,Krista Fischer,Victor Blanchette,Peter William Collins +9 more
TL;DR: The relationships of the PK of factor VIII (FVIII) with age and body weight by a population PK model can be used as a basis for PK-based dose tailoring of FVIII in clinical practice, in all age groups, with minimal blood sampling.
Journal ArticleDOI
Factor VIII requirement to maintain a target plasma level in the prophylactic treatment of severe hemophilia A: influences of variance in pharmacokinetics and treatment regimens
Peter William Collins,Sven Björkman,Krista Fischer,Victor Blanchette,Myungshin Oh,Phillip Schroth,Sandor Fritsch,Kathleen M. Casey,Gerald Spotts,Bruce M. Ewenstein +9 more
TL;DR: Knowledge of individual patients’ half‐lives and alteration of frequency of infusions may allow the more cost‐effective use of FVIII and potentially expand access to prophylaxis to a greater number of patients, especially in regions where healthcare resources are scarce.
Journal ArticleDOI
Comparative pharmacokinetics of plasma- and albumin-free recombinant factor VIII in children and adults: the influence of blood sampling schedule on observed age-related differences and implications for dose tailoring.
Sven Björkman,Victor S. Blanchette,Krista Fischer,Myungshin Oh,Gerald Spotts,Phillip Schroth,Sandor Fritsch,Lisa Patrone,Bruce M. Ewenstein,Peter William Collins +9 more
TL;DR: Investigation of the contribution of both biological and methodological factors to the observed variability of factor VIII (FVIII) PK found low intrapatient variability supports the use of PK measurements for dose tailoring of FVIII.