S
Sandra A. Moore
Researcher at Brigham and Women's Hospital
Publications - 14
Citations - 6692
Sandra A. Moore is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Polycythemia vera & Myelofibrosis. The author has an hindex of 12, co-authored 14 publications receiving 6333 citations. Previous affiliations of Sandra A. Moore include Harvard University & Howard Hughes Medical Institute.
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Journal ArticleDOI
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis.
Ross L. Levine,Ross L. Levine,Martha Wadleigh,Jan Cools,Benjamin L. Ebert,Benjamin L. Ebert,Gerlinde Wernig,Brian J. P. Huntly,Titus J. Boggon,Iwona Wlodarska,Jennifer J. Clark,Sandra A. Moore,Jennifer Adelsperger,Sumin Koo,Jeffrey C. Lee,Stacey Gabriel,Thomas Mercher,Alan D. D'Andrea,Stefan Fröhling,Konstanze Döhner,Peter Marynen,Peter Vandenberghe,Ruben A. Mesa,Ayalew Tefferi,James D. Griffin,Michael J. Eck,William R. Sellers,William R. Sellers,Matthew Meyerson,Matthew Meyerson,Todd R. Golub,Todd R. Golub,Todd R. Golub,Stephanie J. Lee,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland +36 more
TL;DR: High-throughput DNA resequencing identified a recurrent somatic missense mutation JAK2V617F in granulocyte DNA samples of 121 of 164 PV patients, of which 41 had homozygous and 80 had heterozygous mutations.
Journal ArticleDOI
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia.
Yana Pikman,Benjamin H. Lee,Thomas Mercher,Elizabeth McDowell,Benjamin L. Ebert,Benjamin L. Ebert,Maricel Gozo,Adam Cuker,Gerlinde Wernig,Sandra A. Moore,Ilene Galinsky,Daniel J. DeAngelo,Jennifer J. Clark,Stephanie J. Lee,Todd R. Golub,Todd R. Golub,Todd R. Golub,Martha Wadleigh,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland,Ross L. Levine,Ross L. Levine +22 more
TL;DR: The JAK2V617F allele has been identified in patients with polycythemia vera (PV), essential thrombocytosis (ET), and myelofibrosis with myeloid metaplasia (MF).
MPLW515L Is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid
Metaplasia Pikman,Benjamin H. Lee,Thomas Mercher,Elizabeth McDowell,Benjamin L. Ebert,Maricel Gozo,Adam Cuker,Gerlinde Wernig,Sandra A. Moore,Ilene Galinsky,Daniel J. DeAngelo,Jennifer J. Clark,Stephanie J. Lee,Todd R. Golub,Martha Wadleigh,D. Gary Gilliland,Ross L. Levine +16 more
TL;DR: Activation of JAK-STAT signaling via MPLW515L is an important pathogenetic event in patients with JAK2V617F-negative MF, including extramedullary hematopoiesis, splenomegaly, and megakaryocytic proliferation.
Journal ArticleDOI
Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-Induced Polycythemia Vera
Gerlinde Wernig,Michael G. Kharas,Rachel Okabe,Sandra A. Moore,Dena S. Leeman,Dana E. Cullen,Maricel Gozo,Elizabeth McDowell,Ross L. Levine,Ross L. Levine,John Doukas,Chi Ching Mak,Glenn Noronha,Michael Martin,Yon D. Ko,Benjamin H. Lee,Richard M. Soll,Ayalew Tefferi,John Hood,D. Gary Gilliland,D. Gary Gilliland,D. Gary Gilliland +21 more
TL;DR: In this article, a small-molecule inhibitor of JAK2 with an in vitro IC50 of approximately 3 nM was used to treat myeloproliferative disease induced by the JAK 2V617F mutation.
Journal ArticleDOI
Activating alleles of JAK3 in acute megakaryoblastic leukemia
Denise K. Walters,Denise K. Walters,Thomas Mercher,Ting-Lei Gu,Thomas O'Hare,Thomas O'Hare,Jeffrey W. Tyner,Marc M. Loriaux,Valerie Goss,Kimberly Lee,Christopher A. Eide,Matthew J. Wong,Eric P. Stoffregen,Laura McGreevey,Julie Nardone,Sandra A. Moore,John D. Crispino,Titus J. Boggon,Michael Heinrich,Michael Heinrich,Michael W. Deininger,Roberto D. Polakiewicz,D. Gary Gilliland,Brian J. Druker,Brian J. Druker +24 more
TL;DR: A screening strategy that rapidly identifies tyrosine-phosphorylated proteins using mass spectrometry allowed the identification of an activating mutation (A572V) in the JAK3 pseudokinase domain in the acute megakaryoblastic leukemia (AMKL) cell line CMK.