Sandra Gordon

TL;DR: It is demonstrated that IL1RAP is a promising new therapeutic target in AML by achieving selective killing of AML MNC, CD34+CD38+, and CD34-CD38- cells using a monoclonal antibody.

TL;DR: The detection of distinct stress-inducible and developmentally regulated HSE-binding activities of endogenous oocyte factors and the kinetics of HSF1 activation in oocytes suggests that a key protein(s) regulating attenuation of the stress response is present at exceedingly low levels or is somehow modified during preembryonic development.

TL;DR: The present inhibitors could serve as a starting point for the development of new antifungal agents with a novel mode of action, and reveal a dual mechanism for the previously identified cationic peptide BM2, revealing fungal membrane disruption, in addition to Pma1 inhibition.

TL;DR: It is found that tetrahydrocarbazoles inhibit adenosine triphosphate (ATP) hydrolysis of thefungal H+-ATPase, depolarize the fungal plasma membrane and exhibit broad-spectrum antifungal activity.

TL;DR: Valproate treatment at pharmacologically relevant doses resulted in upregulation of CD20 in vivo, and also in expected epigenetic modifications, which suggests that pre-treatment with valproate or other HDACis before anti-CD20 therapy could be advantageous in CD20-low B-cell lymphomas.