S
Sandra L. Schmid
Researcher at University of Texas Southwestern Medical Center
Publications - 209
Citations - 32222
Sandra L. Schmid is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Endocytosis & Dynamin. The author has an hindex of 89, co-authored 209 publications receiving 30096 citations. Previous affiliations of Sandra L. Schmid include University of British Columbia & Stanford University.
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Journal ArticleDOI
Regulation of clathrin-mediated endocytosis by hierarchical allosteric activation of AP2.
Zuzana Kadlecova,Stephanie J. Spielman,Dinah Loerke,Aparna Mohanakrishnan,Dana Kim Reed,Sandra L. Schmid +5 more
TL;DR: In this article, the authors used quantitative live-cell analyses to measure discrete early stages of CME and show how sequential, allosterically regulated conformational changes activate AP2 to drive both nucleation and subsequent stabilization of nascent CCPs.
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Isoform and Splice-Variant Specific Functions of Dynamin-2 Revealed by Analysis of Conditional Knock-Out Cells
TL;DR: Surprisingly, CME and p75 exocytosis were efficiently rescued by reintroduction of Dyn2, but not Dyn1, suggesting that these two isoforms function differentially in vesicular trafficking in nonneuronal cells.
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A molecular motor or a regulator? Dynamin's in a class of its own
Byeong Doo Song,Sandra L. Schmid +1 more
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Dissociation of clathrin coats coupled to the hydrolysis of ATP: role of an uncoating ATPase.
TL;DR: The 70,000-mol-wt protein, purified on the basis of its ATP-dependent ability to disassembleClathrin cages, was found to possess a clathrin-dependent ATPase activity, indicating that the hydrolytic site for ATP resides on the uncoating protein.
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Hsc70 is required for endocytosis and clathrin function in Drosophila.
TL;DR: Genetic support for the long-suspected role of Hsc70 in clathrin-mediated endocytosis is provided, at least in part by inhibiting the uncoating of CCVs.