S
Sandra L. Schmid
Researcher at University of Texas Southwestern Medical Center
Publications - 209
Citations - 32222
Sandra L. Schmid is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Endocytosis & Dynamin. The author has an hindex of 89, co-authored 209 publications receiving 30096 citations. Previous affiliations of Sandra L. Schmid include University of British Columbia & Stanford University.
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Journal ArticleDOI
Ap-2/eps15 interaction is required for receptor-mediated endocytosis
Alexandre Benmerah,Christophe Lamaze,Bernadette Bègue,Sandra L. Schmid,Alice Dautry-Varsat,Nadine Cerf-Bensussan +5 more
TL;DR: Results show that interaction of Eps15 with AP-2 is required for efficient receptor-mediated endocytosis and thus provide the first evidence that Eps15 is involved in the function of plasma membrane–coated pits.
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Advances in Analysis of Low Signal-to-Noise Images Link Dynamin and AP2 to the Functions of an Endocytic Checkpoint
TL;DR: A framework for unbiased measurement of EAP recruitment to CCPs and their direct effects on CCP dynamics is presented and dynamin and the EAP-binding α-adaptin appendage domain of the AP2 adaptor are identified as switches in a regulated, multistep maturation process and provide direct evidence for a molecular checkpoint in CME.
Journal ArticleDOI
Regulation of Clathrin-Mediated Endocytosis.
TL;DR: This review summarizes recent findings on the regulation of CME and the evolution of this complex process and describes the role of the GTPase dynamin in this process.
Journal ArticleDOI
Regulation of Macropinocytosis by p21-activated Kinase-1
Suranganie Dharmawardhane,Annette Schürmann,Mary Ann Sells,Jonathan Chernoff,Sandra L. Schmid,Gary M. Bokoch +5 more
TL;DR: The mechanisms by which PAK modulate macropinocytosis were examined in NIH3T3 cell lines expressing various PAK1 constructs under the control of a tetracycline-responsive transactivator, and data indicate that PAK 1 plays an important regulatory role in the process of macropInocyTosis.
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Identification of an adaptor-associated kinase, AAK1, as a regulator of clathrin-mediated endocytosis
Sean D. Conner,Sandra L. Schmid +1 more
TL;DR: A novel member of the Prk/Ark family of serine/threonine kinases, adaptor-associated kinase (AAK)1 is identified and it is found that AAK1 copurifies with adaptor protein (AP)2 and that it directly binds the ear domain of α-adaptin in vivo and in vitro.