S
Sandra Pinkert
Researcher at Humboldt University of Berlin
Publications - 38
Citations - 965
Sandra Pinkert is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Coxsackievirus & Virus. The author has an hindex of 17, co-authored 37 publications receiving 844 citations. Previous affiliations of Sandra Pinkert include Technical University of Berlin & Charité.
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Journal ArticleDOI
Cardiac-targeted RNA interference mediated by an AAV9 vector improves cardiac function in coxsackievirus B3 cardiomyopathy
Henry Fechner,Isaac Sipo,Dirk Westermann,Sandra Pinkert,Xiaomin Wang,Lennart Suckau,Jens Kurreck,Heinz Zeichhardt,Oliver J. Müller,Roland Vetter,Volker A. Erdmann,Carsten Tschöpe,Wolfgang Poller +12 more
TL;DR: Targeted RNAi for the treatment of a viral cardiomyopathy, which is a major cause of sudden cardiac death or terminal heart failure in children and young adults, is reported and intravenously injected AAV9 has the potential to target RNAi to the heart and is suggested as a novel therapeutic approach for cardiac disorders.
Journal ArticleDOI
Proteomic Analysis of the Multimeric Nuclear Egress Complex of Human Cytomegalovirus
Jens Milbradt,Alexandra Kraut,Alexandra Kraut,Corina Hutterer,Eric Sonntag,Cathrin Schmeiser,Myriam Ferro,Myriam Ferro,Sabrina Wagner,Tihana Lenac,Claudia Claus,Sandra Pinkert,Stuart T. Hamilton,William D. Rawlinson,Heinrich Sticht,Yohann Couté,Yohann Couté,Manfred Marschall +17 more
TL;DR: These data prove the functional importance of emerin as an NEC component, associated with pUL50, pUL53, pul97, p32/gC1qR, and further regulatory proteins, and provide the first proteomics-based characterization and functional validation of the HCMV-specific multimeric NEC.
Journal ArticleDOI
Prevention of Cardiac Dysfunction in Acute Coxsackievirus B3 Cardiomyopathy by Inducible Expression of a Soluble Coxsackievirus-Adenovirus Receptor
Sandra Pinkert,Dirk Westermann,Xiaomin Wang,Karin Klingel,Andrea Dörner,Konstantinos Savvatis,Tobias Grössl,Stefanie Krohn,Carsten Tschöpe,Heinz Zeichhardt,Katja Kotsch,Kerstin Weitmann,Wolfgang Hoffmann,Heinz-Peter Schultheiss,Owen B. Spiller,Wolfgang Poller,Henry Fechner +16 more
TL;DR: AdG12-mediated sCAR-Fc delivery prevents cardiac dysfunction in CVB3 myocarditis under prophylactic and therapeutic conditions and hemodynamics of animals treated with AdG12 (plus doxycycline) were similar to uninfected controls.
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Virus-Host Coevolution in a Persistently Coxsackievirus B3-Infected Cardiomyocyte Cell Line
Sandra Pinkert,Karin Klingel,Vanessa Lindig,Andrea Dörner,Heinz Zeichhardt,Owen B. Spiller,Henry Fechner,Henry Fechner +7 more
TL;DR: This is the first report of a CVB3 carrier-state infection in a cardiomyocyte cell line, revealing natural coevolution of CAR downregulation with CAR-independent viral entry in resistant host cells as an important mechanism of induction ofCVB3 persistence.
Journal ArticleDOI
Coxsackievirus B3 and adenovirus infections of cardiac cells are efficiently inhibited by vector-mediated RNA interference targeting their common receptor
Henry Fechner,Sandra Pinkert,Xiaomin Wang,Isaac Sipo,Lennart Suckau,Jens Kurreck,Andrea Dörner,Sollerbrant K,Heinz Zeichhardt,Hans-Peter Grunert,Roland Vetter,Heinz P. Schultheiss,Wolfgang Poller +12 more
TL;DR: It is concluded that CAR knockout by shRNA vectors is efficient against CoxB3 and adenovirus in primary cardiac cells, but the efficacy of this approach in vivo may be influenced by cell type-specific silencing kinetics in different tissues.