S
Sanjeev Shukla
Researcher at Indian Institute of Science Education and Research, Bhopal
Publications - 38
Citations - 2221
Sanjeev Shukla is an academic researcher from Indian Institute of Science Education and Research, Bhopal. The author has contributed to research in topics: Alternative splicing & RNA splicing. The author has an hindex of 13, co-authored 31 publications receiving 1846 citations. Previous affiliations of Sanjeev Shukla include Cancer Research Institute.
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CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing
Sanjeev Shukla,Ersen Kavak,Ersen Kavak,Melissa Gregory,Masahiko Imashimizu,Bojan Shutinoski,Mikhail Kashlev,Philipp Oberdoerffer,Rickard Sandberg,Rickard Sandberg,Shalini Oberdoerffer +10 more
TL;DR: This work provides the first evidence that a DNA-binding protein, CCCTC-binding factor (CTCF), can promote inclusion of weak upstream exons by mediating local RNA polymerase II pausing both in a mammalian model system for alternative splicing, CD45, and genome-wide.
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Apigenin and cancer chemoprevention: Progress, potential and promise (Review)
TL;DR: Appigenin has been shown to possess remarkable anti-inflammatory, antioxidant and anti-carcinogenic properties, and its considerable potential for development as a cancer chemopreventive agent is evaluated.
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TET-catalyzed oxidation of intragenic 5-methylcytosine regulates CTCF-dependent alternative splicing.
Ryan J. Marina,David Sturgill,Marc Bailly,Morgan Thenoz,Garima Varma,Maria F. Prigge,Kyster K. Nanan,Sanjeev Shukla,Nazmul Haque,Shalini Oberdoerffer +9 more
TL;DR: The methylcytosine dioxygenases TET1 and TET2 are revealed as active regulators of CTCF‐mediated alternative splicing through conversion of 5‐methylcyTosine to its oxidation derivatives, significantly expanding the current concept of the pre‐mRNA “splicing code” to include dynamic intragenic DNA methylation catalyzed by the TET proteins.
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Chamomile: An anti-inflammatory agent inhibits inducible nitric oxide synthase expression by blocking RelA/p65 activity
TL;DR: It is demonstrated that chamomile inhibits NO production and iNOS gene expression by inhibiting RelA/p65 activation and supports the utilization of chamamile as an effective anti-inflammatory agent.
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Single-Site Labeling of Native Proteins Enabled by a Chemoselective and Site-Selective Chemical Technology
Srinivasa Rao Adusumalli,Dattatraya Gautam Rawale,Usha Singh,Prabhanshu Tripathi,Rajesh Paul,Neetu Kalra,Ram Kumar Mishra,Sanjeev Shukla,Vishal Rai +8 more
TL;DR: The linchpin directed modification (LDM) provides a convenient route for the conjugation of a fluorophore and drug to a Fab and monoclonal antibody and delivers trastuzumab-doxorubicin andtrastuzuab-emtansine conjugates with selective antiproliferative activity toward Her-2 positive SKBR-3 breast cancer cells.