S
Sankaran Krishnaswamy
Researcher at Madurai Kamaraj University
Publications - 49
Citations - 1970
Sankaran Krishnaswamy is an academic researcher from Madurai Kamaraj University. The author has contributed to research in topics: Porin & Prophage. The author has an hindex of 19, co-authored 49 publications receiving 1914 citations. Previous affiliations of Sankaran Krishnaswamy include Centre national de la recherche scientifique & Purdue University.
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Journal ArticleDOI
Class II aminoacyl transfer RNA synthetases: crystal structure of yeast aspartyl-tRNA synthetase complexed with tRNA(Asp)
Marc Ruff,Sankaran Krishnaswamy,M. Boeglin,Arnaud Poterszman,Andre Mitschler,Alberto Podjarny,Bernard Rees,Jean-Claude Thierry,Dino Moras +8 more
TL;DR: The crystal structure of the binary complex tRNA(Asp)-aspartyl tRNA synthetase from yeast was solved with the use of multiple isomorphous replacement to 3 angstrom resolution.
Journal ArticleDOI
Atomic structure of single-stranded DNA bacteriophage ΦX174 and its functional implications
Robert McKenna,Di Xia,Di Xia,Peter Willingmann,Peter Willingmann,Leodevico L. Ilag,Leodevico L. Ilag,Sankaran Krishnaswamy,Sankaran Krishnaswamy,Michael G. Rossmann,Norman H. Olson,Timothy S. Baker,Nino L. Incardona +12 more
TL;DR: The mechanism of DNA ejection, viral assembly and evolution are related to the structure of bacteriophage ΦX174, a T = 1 capsid whose major folding motif is the eight–stranded antiparallelβ barrel found in many other icosahedral viruses.
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Structural analysis of a series of antiviral agents complexed with human rhinovirus 14
John Badger,Iwona Minor,Marcia J. Kremer,Marcos A. Oliveira,Thomas J. Smith,James P. Griffith,Diego M. A. Guérin,Sankaran Krishnaswamy,Ming Luo,Michael G. Rossmann,Mark A. McKinlay,Guy D. Diana,Frank J. Dutko,Marilyn Fancher,Roland R. Rueckert,Beverly A. Heinz +15 more
TL;DR: Crystallographic studies of one of these mutants confirm the partial sequencing data and support the finding that this is a single mutation that occurs within the binding pocket, and are consistent with their observed antiviral activities against human rhinovirus 14 drug-resistant mutants and other rhinOVirus serotypes.
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C—H⋯O Hydrogen Bonds in β‐sheets
TL;DR: A detailed analysis of the occurrence of the C-H...O hydrogen bonds in sheet regions of proteins has been presented and an inverse correlation is observed between the hydrogen-bond geometries involving the C(alpha)(i)-h...O=C and the N(i+1)-H...
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Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
Bérénice A. Benayoun,Sandrine Caburet,Aurélie Dipietromaria,Adrien Georges,Adrien Georges,Barbara D'haene,P. J. Eswari Pandaranayaka,David L'Hôte,Anne-Laure Todeschini,Sankaran Krishnaswamy,Marc Fellous,Elfride De Baere,Reiner A. Veitia +12 more
TL;DR: This is the first study demonstrating that the p.Cys134Trp mutant does not have a strong impact on FOXL2 localization, solubility, and transactivation abilities on a panel of proven target promoters, behaving neither as a dominant-negative nor as a loss-of-function mutation.