A
Aurélie Dipietromaria
Researcher at Centre national de la recherche scientifique
Publications - 12
Citations - 575
Aurélie Dipietromaria is an academic researcher from Centre national de la recherche scientifique. The author has contributed to research in topics: Transcription factor & Promoter. The author has an hindex of 12, co-authored 12 publications receiving 544 citations. Previous affiliations of Aurélie Dipietromaria include Paris Descartes University & French Institute of Health and Medical Research.
Papers
More filters
Journal ArticleDOI
Transcription factor FOXL2 protects granulosa cells from stress and delays cell cycle: role of its regulation by the SIRT1 deacetylase
Bérénice A. Benayoun,Adrien Georges,Adrien Georges,Adrien Georges,David L'Hôte,David L'Hôte,Noora Andersson,Aurélie Dipietromaria,Aurélie Dipietromaria,Anne-Laure Todeschini,Anne-Laure Todeschini,Sandrine Caburet,Sandrine Caburet,Claude Bazin,Claude Bazin,Mikko Anttonen,Reiner A. Veitia,Reiner A. Veitia +17 more
TL;DR: The body of evidence presented here supports the idea that FOXL2 plays a key role in granulosa cell homeostasis, the failure of which is central to ovarian ageing and tumorigenesis.
Journal ArticleDOI
Differential aggregation and functional impairment induced by polyalanine expansions in FOXL2, a transcription factor involved in cranio-facial and ovarian development
Lara Moumné,Aurélie Dipietromaria,Aurélie Dipietromaria,Aurélie Dipietromaria,Frank Batista,Frank Batista,Frank Batista,Ayhan Kocer,Marc Fellous,Eric Pailhoux,Reiner A. Veitia +10 more
TL;DR: A functional study of the effects of polyAla expansions in the context of the transcription factor FOXL2, involved in cranio-facial and ovarian development, shows that FoxL2 polyAlA expansions lead to protein mislocalization and aggregation in a length-dependent manner.
Journal ArticleDOI
Functional Exploration of the Adult Ovarian Granulosa Cell Tumor-Associated Somatic FOXL2 Mutation p.Cys134Trp (c.402C>G)
Bérénice A. Benayoun,Sandrine Caburet,Aurélie Dipietromaria,Adrien Georges,Adrien Georges,Barbara D'haene,P. J. Eswari Pandaranayaka,David L'Hôte,Anne-Laure Todeschini,Sankaran Krishnaswamy,Marc Fellous,Elfride De Baere,Reiner A. Veitia +12 more
TL;DR: This is the first study demonstrating that the p.Cys134Trp mutant does not have a strong impact on FOXL2 localization, solubility, and transactivation abilities on a panel of proven target promoters, behaving neither as a dominant-negative nor as a loss-of-function mutation.
Journal ArticleDOI
The identification and characterization of a FOXL2 response element provides insights into the pathogenesis of mutant alleles.
Bérénice A. Benayoun,Sandrine Caburet,Aurélie Dipietromaria,Marc Bailly-Bechet,Frank Batista,Frank Batista,Frank Batista,Marc Fellous,Marc Fellous,Daniel Vaiman,Daniel Vaiman,Daniel Vaiman,Reiner A. Veitia +12 more
TL;DR: It is shown that polyAlanine expansions of FOXL2, which are the most frequent pathogenic mutations, induce a length-dependent loss of response on different artificial promoter reporters depending on the number and sequence of the FLREs that they contain, providing clear mechanistic evidence explaining how the architecture of promoters influences their sensitivity to decreased transcription factor availability.
Journal ArticleDOI
Functional evidence implicating FOXL2 in non-syndromic premature ovarian failure and in the regulation of the transcription factor OSR2
Paul Laissue,Besma Lakhal,Bérénice A. Benayoun,Aurélie Dipietromaria,Rim Braham,Hatem Elghezal,Pascal Philibert,Ali Saâd,Charles Sultan,Marc Fellous,Reiner A. Veitia +10 more
TL;DR: The data provide evidence in favour of the implication ofFOXL2 variants in non-syndromic POF and confirm the regulatory interaction between FOXL2 and OSR2 whose perturbation might contribute to the palpebral abnormalities observed in BPES patients.