Santiago Ambrosio

TL;DR: The results indicate that an improper handling of dysfunctional mitochondria may be a leading event in PD pathogenesis.

TL;DR: It is concluded that dopamine may affect NADH and NADPH oxidation directly, when the intracellular concentrations of NAD(P)H and oxidized dopamine are similar, which triggers a redox cycle with dopamine that leads to its own consumption.

TL;DR: The levels of brain PFK-2/FBPase-2 gene expression as well as the enzymatic activity and the concentration of Fru-2,6-P(2) appear to be remarkably constant during adult life, without significant differences in the brain hippocampus, cortex, cerebellum or striatum areas.

TL;DR: In this organ, the levels of dopamine metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were significantly lower after MPTP treatment, and biochemical changes caused by MPTP with respect to its effects on the peripheral catecholaminergic organs are discussed.

TL;DR: It is demonstrated that citicoline affects the staurosporine-induced apoptosis cell-signalling pathway by interacting with the glutathione system and by inhibiting caspase-3 in SH-SY5Y human neuroblastoma cells.