S
Sara Fröjdö
Researcher at French Institute of Health and Medical Research
Publications - 6
Citations - 928
Sara Fröjdö is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Resveratrol & Insulin resistance. The author has an hindex of 6, co-authored 6 publications receiving 872 citations. Previous affiliations of Sara Fröjdö include Claude Bernard University Lyon 1.
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Journal ArticleDOI
Resveratrol: One molecule, many targets
Luciano Pirola,Sara Fröjdö +1 more
TL;DR: It appears that resveratrol, as a pharmacological agent, has a wide spectrum of targets and may be dependent on its simultaneous activity on multiple molecular targets.
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Alterations of insulin signaling in type 2 diabetes: A review of the current evidence from humans
TL;DR: The studies on humans exploring the defects of the insulin signaling cascade generated by insulin resistance and type 2 diabetes are reviewed, focusing on muscle and adipose tissue - which account for most of the glucose disposal capacity of the body - with focus on the unresolved discrepancies present in the literature.
Journal ArticleDOI
Resveratrol is a class IA phosphoinositide 3-kinase inhibitor.
TL;DR: It is shown that resveratrol inhibits, in vitro and in cultured muscle cell lines, class IA PI3K and its downstream signalling at the same concentration range at which it activates sirtuins.
Journal ArticleDOI
Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1
Sara Fröjdö,Christine Durand,Laurent Molin,Laurent Molin,Andrew L. Carey,Assam El-Osta,Bronwyn A. Kingwell,Mark A. Febbraio,Florence Solari,Florence Solari,Hubert Vidal,Luciano Pirola +11 more
TL;DR: SIRT1 is identified as a positive modulator of insulin signaling in muscle cells through PI3K, and this mechanism appears to be conserved from C. elegans through humans.
Journal ArticleDOI
Isoform-specific defects of insulin stimulation of Akt/protein kinase B (PKB) in skeletal muscle cells from type 2 diabetic patients.
Delphine Cozzone,Sara Fröjdö,Emmanuel Disse,Cyrille Debard,Martine Laville,Luciano Pirola,Hubert Vidal +6 more
TL;DR: Muscle cells from diabetic patients displayed defective insulin action and a drastic reduction of insulin-stimulated activity of all Akt isoforms, and higher levels of the Akt2-Ser473-specific protein phosphatase PH domain leucine-rich repeat proteinosphatase 1 (PHLPP1) in muscle from diabetes patients are found, which may contribute to the alteration of Akt1-Thr308 phosphorylation.