Sara L. Hillman

TL;DR: Replication studies should integrate genomics and transcriptomics with longitudinal sampling to elucidate stability, determine causality for translation into biomarker and prevention studies, and integrateGenetic variation in foetal tissue may have a mechanistic role in metabolic disease programming through interaction of the pregnancy environment with gene function.

TL;DR: DNA from umbilical cord blood of FGR born at term had 839 differentially methylated positions (DMPs) that reached genome-wide significance compared with AGA, and Gene Ontology analysis of DMPs supported their involvement in gene regulation and transcription pathways related to organ development and metabolic function.

TL;DR: A fetal-specific program of protective immunity whose dysregulation is associated with fetal and neonatal inflammatory pathologies is revealed.

TL;DR: Men who recently fathered growth-restricted offspring have preclinical evidence of the insulin resistance syndrome and are more likely to smoke than fathers of normal grown offspring, and paternal lifestyle may influence heritable factors important for fetal growth.

TL;DR: In this article, the role of placental Slc38a2/SNAT2 deficiency in the development of restricted fetal growth was investigated in mice, and the placenta-specific Slc 38a2 deficiency was found to cause late-onset fetal growth restriction.