L
Lucy R. Marshall
Researcher at University College London
Publications - 8
Citations - 833
Lucy R. Marshall is an academic researcher from University College London. The author has contributed to research in topics: Juvenile dermatomyositis & Antibody. The author has an hindex of 3, co-authored 7 publications receiving 473 citations. Previous affiliations of Lucy R. Marshall include Great Ormond Street Hospital & National Institute for Health Research.
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Journal ArticleDOI
Preexisting and de novo humoral immunity to SARS-CoV-2 in humans
Kevin W. Ng,Nikhil Faulkner,Georgina H. Cornish,Annachiara Rosa,Ruth Harvey,Saira Hussain,Rachel Ulferts,Christopher Earl,A.G. Wrobel,D.J. Benton,Chloe Roustan,William Bolland,Rachael Thompson,Ana Agua-Doce,Philip Hobson,Judith Heaney,Hannah Rickman,Stavroula Paraskevopoulou,Catherine F Houlihan,Kirsty Thomson,Emilie Sanchez,Gee Yen Shin,Moira J. Spyer,Dhira Joshi,Nicola O’Reilly,Philip A. Walker,Svend Kjaer,Andrew Riddell,Catherine Moore,Bethany R. Jebson,Meredyth G. Ll Wilkinson,Lucy R. Marshall,Elizabeth C. Rosser,Anna Radziszewska,Hannah Peckham,Coziana Ciurtin,Lucy R. Wedderburn,Rupert Beale,Charles Swanton,Sonia Gandhi,Brigitta Stockinger,John W. McCauley,Steve Gamblin,Laura E. McCoy,Peter Cherepanov,Eleni Nastouli,George Kassiotis,George Kassiotis +47 more
TL;DR: Using diverse assays for antibodies recognizing SARS-CoV-2 proteins, preexisting humoral immunity was detected and antibodies targeting the S2 subunit were particularly prevalent in children and adolescents.
Journal ArticleDOI
CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
Joanna Halkias,Elze Rackaityte,Sara L. Hillman,Dvir Aran,Ventura F. Mendoza,Lucy R. Marshall,Tippi C. MacKenzie,Trevor D. Burt +7 more
TL;DR: A fetal-specific program of protective immunity whose dysregulation is associated with fetal and neonatal inflammatory pathologies is revealed.
Journal ArticleDOI
Expression of myxovirus-resistance protein A: a possible marker of muscle disease activity and autoantibody specificities in juvenile dermatomyositis.
Sirisucha Soponkanaporn,Sirisucha Soponkanaporn,Claire T Deakin,Peter W. Schutz,Peter W. Schutz,Peter W. Schutz,Lucy R. Marshall,SA Yasin,Cerise M Johnson,Erdal Sag,Erdal Sag,Sarah L Tansley,Neil McHugh,Lucy R. Wedderburn,Thomas S. Jacques +14 more
TL;DR: To evaluate the relationship between expression of myxovirus‐resistance protein A (MxA) protein on muscle biopsies by immunohistochemistry and disease activity in juvenile dermatomyositis (JDM) patients, and to investigate whether the expression of MxA is related with myositis‐specific autoantibodies (MSA) status in JDM patients.
Journal ArticleDOI
Gene therapy restores dopamine transporter expression and ameliorates pathology in iPSC and mouse models of infantile parkinsonism.
Joanne Ng,Serena Barral,Carmen De La Fuente Barrigon,Gabriele Lignani,Fatma A. Erdem,Fatma A. Erdem,Rebecca L. Wallings,Riccardo Privolizzi,Giada Rossignoli,Haya Alrashidi,Sonja Heasman,Esther Meyer,Adeline Ngoh,Simon Pope,Rajvinder Karda,Dany P. Perocheau,Julien Baruteau,Natalie Suff,Natalie Suff,Juan Antinao Diaz,Stephanie Schorge,Jane Vowles,Lucy R. Marshall,Sally A. Cowley,Sonja Sucic,Michael Freissmuth,John R. Counsell,Richard Wade-Martins,Simon Heales,Ahad A. Rahim,M. Bencze,M. Bencze,Simon N. Waddington,Simon N. Waddington,Manju A Kurian,Manju A Kurian +35 more
TL;DR: In this article, a midbrain dopaminergic (mDA) neuron model of DTDS was generated using patient-derived induced pluripotent stem cells (iPSCs), which exhibited marked impairment of DAT activity, apoptotic neurodegeneration associated with TNFα-mediated inflammation, and dopamine toxicity.
Journal ArticleDOI
Association with HLA-DRβ1 position 37 distinguishes juvenile dermatomyositis from adult-onset myositis
Claire T Deakin,John Bowes,Lisa G. Rider,Frederick W. Miller,Lauren M. Pachman,Helga Sanner,Kelly Rouster-Stevens,Gulnara Mamyrova,Rodolfo Curiel,Brian M. Feldman,Adam M. Huber,Ann M. Reed,Heinrike Schmeling,Charlotte G Cook,Lucy R. Marshall,Meredyth G. Ll Wilkinson,Steve Eyre,Soumya Raychaudhuri,Lucy R. Wedderburn +18 more
TL;DR: A JDM-focused genetic analysis was performed using the largest collection of JDM samples to date to identify a novel association with amino acid position 37 within HLA-DRB1, which may distinguish JDM from adult DM.