Sarah Dreikorn

TL;DR: The minimum effective concentration assay was related to inhibition of glucan synthase activity in vitro and may provide a starting point for development of susceptibility testing methods for lipopeptides.

TL;DR: Results of natural-product screening by a series of newly developed methods has led to the identification of four acidic terpenoid (1,3)-β-d-glucan synthase inhibitors, which have limited oral bioavailability and in vitro antifungal activity comparable to that of L-733560, a close analogue of MK-0991.

TL;DR: Rustmicin has potent fungicidal activity against clinically important human pathogens that is correlated with its sphingolipid inhibition and was found to be a remarkably good substrate for the Saccharomyces cerevisiae multidrug efflux pump encoded by PDR5.

TL;DR: It is shown that viridiofungins are potent in vitro inhibitors of serine palmitoyltransferase, the first committed enzyme in sphingolipid biosynthesis, and their antifungal activity is due to inhibition of sphingoipid synthesis.

TL;DR: Results support the notion that the enhanced antifungal activity of L-733,560 is achieved by superior inhibition of glucan synthesis and not by nonspecific membrane effects or a second mode of action.