H
Herbert G. Bull
Researcher at Merck & Co.
Publications - 28
Citations - 5209
Herbert G. Bull is an academic researcher from Merck & Co.. The author has contributed to research in topics: Alanine racemase & Granzyme B. The author has an hindex of 22, co-authored 28 publications receiving 4969 citations.
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Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
The target of ezetimibe is Niemann-Pick C1-Like 1 (NPC1L1).
Margarita Garcia-Calvo,JeanMarie Lisnock,Herbert G. Bull,Brian E. Hawes,Duane A. Burnett,Matthew P. Braun,James H. Crona,Harry R. Davis,Dennis C. Dean,Patricia A. Detmers,Michael P. Graziano,Meredith Hughes,D. Euan MacIntyre,Anthony Ogawa,Kim O’Neill,Sai Prasad N Iyer,Diane E. Shevell,Marsha Smith,Yui S. Tang,Amanda M. Makarewicz,Feroze Ujjainwalla,Scott W. Altmann,Kevin T. Chapman,Nancy A. Thornberry +23 more
TL;DR: A binding assay is developed and shown that labeled ezetimibe glucuronide binds specifically to a single site in brush border membranes and to human embryonic kidney 293 cells expressing NPC1L1, which unequivocally establish NPC1 L1 as the direct target of ezETimibe and should facilitate efforts to identify the molecular mechanism of cholesterol transport.
Journal Article
Carboxyl-terminal tripeptidyl hydrolysis of substance P by purified rabbit lung angiotensin-converting enzyme and the potentiation of substance P activity in vivo by captopril and MK-422.
Margaret A. Cascieri,Herbert G. Bull,R A Mumford,Arthur A. Patchett,Nancy A. Thornberry,T Liang +5 more
TL;DR: The angiotensin-converting enzyme may be one of the enzymes that degrade substance P in vivo and potentiate the substance P-induced stimulation of salivation in rats.
Journal ArticleDOI
Antistasin, a Leech-derived Inhibitor of Factor Xa: Kinetic analysis of enzyme inhibition and identification of the reactive site
C Dunwiddie,Nancy A. Thornberry,Herbert G. Bull,Mohinder K. Sardana,Paul A. Friedman,John W. Jacobs,Ellen Simpson +6 more
TL;DR: Data indicate that the leech has evolved a highly selective and potent inhibitor of coagulation Factor Xa that shares several mechanistic similarities with other serine proteinase inhibitors.
Journal ArticleDOI
UDP-N-acetylglucosamine acyltransferase of Escherichia coli. The first step of endotoxin biosynthesis is thermodynamically unfavorable.
Matt S. Anderson,Herbert G. Bull,S. M. Galloway,Theresa M. Kelly,Sandhya Mohan,K. Radika,Christian R. H. Raetz +6 more
TL;DR: Although UDP-GlcNAc acyltransferase catalyzes the first unique step of lipid A biosynthesis, it is the second enzyme (the deacetylase) that commits the substrates to this pathway, which is not predicted by model S-->O acyl transfer reactions.