S
Sarah Ferber
Researcher at Sheba Medical Center
Publications - 37
Citations - 2706
Sarah Ferber is an academic researcher from Sheba Medical Center. The author has contributed to research in topics: Transdifferentiation & Pancreas. The author has an hindex of 17, co-authored 35 publications receiving 2570 citations. Previous affiliations of Sarah Ferber include Tel Aviv University.
Papers
More filters
Journal ArticleDOI
Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia.
Sarah Ferber,Amir Halkin,Hofit Cohen,Idit Ber,Idit Ber,Yulia Einav,Iris Goldberg,Iris Barshack,Rhona Seijffers,Rhona Seijffers,Juri Kopolovic,Juri Kopolovic,Nurit Kaiser,Avraham Karasik,Avraham Karasik +14 more
TL;DR: The capacity of PDX-1 to reprogram extrapancreatic tissue towards a β-cell phenotype, may provide a valuable approach for generating ‘self’ surrogate β cells, suitable for replacing impaired islet-cell function in diabetics.
Journal ArticleDOI
STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells
TL;DR: It is concluded that expression of GLUT2 is required for efficient killing of neuroendocrine cells by STZ, and this effect is related to specific recognition of the drug as a transported substrate by GLut2 but not GLUT1.
Journal ArticleDOI
Cell-replacement therapy for diabetes: Generating functional insulin-producing tissue from adult human liver cells
Tamar Sapir,Keren Shternhall,Irit Meivar-Levy,Tamar Blumenfeld,Hamutal Cohen,Ehud Skutelsky,Smadar Eventov-Friedman,Iris Barshack,Iris Goldberg,Sarah Pri-Chen,Lya Ben-Dor,Sylvie Polak-Charcon,Avraham Karasik,Ilan Shimon,Eytan Mor,Sarah Ferber +15 more
TL;DR: Inducing developmental redirection of adult liver offers the potential of a cell-replacement therapy for diabetics by allowing the patient to be the donor of his own insulin-producing tissue.
Journal ArticleDOI
Functional, Persistent, and Extended Liver to Pancreas Transdifferentiation
Idit Ber,Keren Shternhall,Keren Shternhall,Keren Shternhall,Shira Perl,Zohar Ohanuna,Zohar Ohanuna,Iris Goldberg,Iris Barshack,Luna Benvenisti-Zarum,Luna Benvenisti-Zarum,Irit Meivar-Levy,Irit Meivar-Levy,Sarah Ferber,Sarah Ferber +14 more
TL;DR: It is concluded that PDX-1 plays an important instructive role in pancreas differentiation, not only from primitive gut endoderm but also from mature liver.
Journal ArticleDOI
Exendin-4 Promotes Liver Cell Proliferation and Enhances the PDX-1-induced Liver to Pancreas Transdifferentiation Process
Vered Aviv,Vered Aviv,Irit Meivar-Levy,Itzhak H. Rachmut,Itzhak H. Rachmut,Tamar Rubinek,Eytan Mor,Sarah Ferber,Sarah Ferber +8 more
TL;DR: Whether the hormone GLP-1 (glucogen-like peptide-1) documented to play a role in pancreatic beta cell differentiation, maturation, and survival, can also increase the efficiency of liver to pancreas transdifferentiation is analyzed and it is demonstrated that the GLp-1R agonist, exendin-4, significantly improves the Efficiency of PDX-1-mediated trans Differentiation.