S
Sarah Fischer
Researcher at University of Cologne
Publications - 9
Citations - 110
Sarah Fischer is an academic researcher from University of Cologne. The author has contributed to research in topics: Autophagy & Dictyostelium discoideum. The author has an hindex of 6, co-authored 8 publications receiving 80 citations.
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ATG16 mediates the autophagic degradation of the 19S proteasomal subunits PSMD1 and PSMD2.
TL;DR: It is proposed that ATG16 links autophagy and the ubiquitin proteasome system, a core autophagosomal protein that is required for their enrichment in ATG8a positive puncta, which mature into autolysosomes.
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The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions
TL;DR: The data show that ATG8a and ATG7b have distinct functions and are involved in canonical as well as non-canonical autophagy, showing that both proteins function in parallel during most analysed cellular processes.
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CDK5RAP2 interaction with components of the Hippo signaling pathway may play a role in primary microcephaly
Salil K. Sukumaran,Maria Stumpf,Sarah Salamon,Ilyas Ahmad,Kurchi Bhattacharya,Sarah Fischer,Rolf Müller,Janine Altmüller,Birgit Budde,Holger Thiele,Muhammad Tariq,Naveed Altaf Malik,Peter Nürnberg,Shahid Mahmood Baig,Muhammad Sajid Hussain,Angelika A. Noegel +15 more
TL;DR: It is proposed that the centrosomal deficiencies and the altered cellular properties in the patient fibroblasts can also result from the observed changes in the Hippo pathway components which could thus be relevant for MCPH and play a role in brain size regulation and development.
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Functional Characterisation of the Autophagy ATG12~5/16 Complex in Dictyostelium discoideum.
Malte A. Karow,Sarah Fischer,Susanne Meßling,Roman Konertz,Jana Riehl,Qiuhong Xiong,Ramesh Rijal,Prerana Wagle,Christoph S. Clemen,Christoph S. Clemen,Christoph S. Clemen,Ludwig Eichinger +11 more
TL;DR: The results confirm the essential function of the ATG12~5/16 complex in canonical autophagy, and furthermore are consistent with autophophagy-independent functions of the complex and its individual components.
Journal ArticleDOI
Functional Characterization of Ubiquitin-Like Core Autophagy Protein ATG12 in Dictyostelium discoideum
Sarah Fischer,Ramesh Rijal,Peter Frommolt,Prerana Wagle,Roman Konertz,Jan Faix,Susanne Meßling,Ludwig Eichinger +7 more
TL;DR: It is shown that ATG12 and ATG16 fulfil autophagy-independent functions in addition to their role in canonical Autophagy, indicating that both proteins also have cellular functions independent of each other.