S
Sarah L. Dallas
Researcher at University of Missouri–Kansas City
Publications - 62
Citations - 6713
Sarah L. Dallas is an academic researcher from University of Missouri–Kansas City. The author has contributed to research in topics: Osteocyte & Osteoblast. The author has an hindex of 35, co-authored 60 publications receiving 6017 citations. Previous affiliations of Sarah L. Dallas include University of Texas Health Science Center at San Antonio & Wellcome Trust Centre for Cell-Matrix Research.
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Journal ArticleDOI
The Osteocyte: An Endocrine Cell … and More
TL;DR: The osteocytes encased within mineralized bone matrix are actually multifunctional cells with many key regulatory roles in bone and mineral homeostasis and should be considered in new strategies to prevent and treat bone disease.
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Proteolysis of Latent Transforming Growth Factor-β (TGF-β)-binding Protein-1 by Osteoclasts A CELLULAR MECHANISM FOR RELEASE OF TGF-β FROM BONE MATRIX
TL;DR: These studies identify LTBP1 as a novel substrate for MMPs and provide the first demonstration that LT BP1 proteolysis may be a physiological mechanism for release of TGF-β from ECM-bound stores, potentially the first step in the pathway by which matrix-bound TGF -β is rendered active.
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Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long-term cultures of fetal rat calvarial osteoblasts
Stephen E. Harris,Lynda F. Bonewald,Marie A. Harris,Massimo Sabatini,Sarah L. Dallas,Jian Q. Feng,Nandini Ghosh-Choudhury,John M. Wozney,Gregory R. Mundy +8 more
TL;DR: The results, showing suppression of markers representative of osteoblast differentiation, suggest that the effects of TGF‐β to stimulate bone formation in vivo are not likely a result of effects on differentiated mineralizing osteoblasts but, as suggested by previous studies, more likely are caused by effects on osteopontin precursors.
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Von Kossa Staining Alone Is Not Sufficient to Confirm that Mineralization In Vitro Represents Bone Formation
Lynda F. Bonewald,Stephen E. Harris,Jennifer L. Rosser,Mark Dallas,Sarah L. Dallas,Nancy P. Camacho,Barbara D. Boyan,Adele L. Boskey +7 more
TL;DR: It is demonstrated that von Kossa staining alone is not appropriate for the identification and quantitation of bonelike mineral and, hence, other techniques such as X-ray diffraction, EM, or FTIR should be utilized to verify the presence and quality of calcium phosphate phases.
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Dynamics of the transition from osteoblast to osteocyte
TL;DR: Recent advances are reviewed that are delineating the changes in gene and protein expression that accompany osteocyte differentiation, which reveal the key role of cell motility in bone cell function and highlight the dynamic nature of mineralized tissues.