S
Sarah Shen
Publications - 2
Citations - 785
Sarah Shen is an academic researcher. The author has contributed to research in topics: Unfolded protein response & Inflammasome. The author has an hindex of 2, co-authored 2 publications receiving 593 citations.
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IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner,John-Paul Upton,P. V.K. Praveen,Rajarshi Ghosh,Yoshimi Nakagawa,Aeid Igbaria,Sarah Shen,Vinh Son Nguyen,Bradley J. Backes,Myriam Heiman,Myriam Heiman,Myriam Heiman,Nathaniel Heintz,Paul Greengard,Simon T. Hui,Qizhi Tang,Ala Trusina,Scott A. Oakes,Feroz R. Papa +18 more
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner,John-Paul Upton,P. V.K. Praveen,Rajarshi Ghosh,Yoshimi Nakagawa,Aeid Igbaria,Sarah Shen,Vinh Son Nguyen,Bradley J. Backes,Nathaniel Heintz,Paul Greengard,Simon T. Hui,Qizhi Tang,Ala Trusina,Scott A. Oakes,Feroz R. Papa,Myriam Heiman +16 more
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.