A
Aeid Igbaria
Researcher at University of Rennes
Publications - 18
Citations - 2103
Aeid Igbaria is an academic researcher from University of Rennes. The author has contributed to research in topics: Endoplasmic reticulum & Unfolded protein response. The author has an hindex of 14, co-authored 18 publications receiving 1679 citations. Previous affiliations of Aeid Igbaria include University of California, San Francisco & Ben-Gurion University of the Negev.
Papers
More filters
Journal ArticleDOI
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner,John-Paul Upton,P. V.K. Praveen,Rajarshi Ghosh,Yoshimi Nakagawa,Aeid Igbaria,Sarah Shen,Vinh Son Nguyen,Bradley J. Backes,Myriam Heiman,Myriam Heiman,Myriam Heiman,Nathaniel Heintz,Paul Greengard,Simon T. Hui,Qizhi Tang,Ala Trusina,Scott A. Oakes,Feroz R. Papa +18 more
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.
Journal ArticleDOI
Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress
Rajarshi Ghosh,Likun Wang,Eric S. Wang,B. Gayani K. Perera,Aeid Igbaria,Shuhei Morita,Kris Prado,Maike Thamsen,Deborah Caswell,Hector Macias,Kurt F. Weiberth,Micah J. Gliedt,Marcel V. Alavi,Sanjay B. Hari,Arinjay K. Mitra,Barun Bhhatarai,Stephan C. Schürer,Erik L. Snapp,Douglas B. Gould,Michael S. German,Bradley J. Backes,Dustin J. Maly,Scott A. Oakes,Feroz R. Papa +23 more
TL;DR: An ATP-competitive IRE1α Kinase-Inhibiting RNase Attenuators-KIRAs-that allosterically inhibit IRE 1α's RNase by breaking oligomers are developed that powerfully controls cell fate but can itself be controlled with small molecules to reduce cell degeneration.
Journal ArticleDOI
Glutathione revisited: a vital function in iron metabolism and ancillary role in thiol-redox control.
Chitranshu Kumar,Aeid Igbaria,Benoît D'Autréaux,Anne-Gaëlle Planson,Christophe Junot,Emmanuel Godat,Anand K. Bachhawat,Agnès Delaunay-Moisan,Michel B. Toledano +8 more
TL;DR: It is proposed that glutathione is essential by its requirement in ISC assembly, but only serves as a thioredoxin backup in cytosolic thiol‐redox maintenance, a model challenging the traditional view of it as prime actor in thiol-redox control.
Journal ArticleDOI
Melanin biosynthesis in the maize pathogen Cochliobolus heterostrophus depends on two mitogen-activated protein kinases, Chk1 and Mps1, and the transcription factor Cmr1.
TL;DR: It is indicated that two MAPKs, Chk1 and Mps1, affect Cmr1 at the transcriptional level and this influence is partially overridden in stress conditions including aging culture and hyperosmotic environment.
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner,John-Paul Upton,P. V.K. Praveen,Rajarshi Ghosh,Yoshimi Nakagawa,Aeid Igbaria,Sarah Shen,Vinh Son Nguyen,Bradley J. Backes,Nathaniel Heintz,Paul Greengard,Simon T. Hui,Qizhi Tang,Ala Trusina,Scott A. Oakes,Feroz R. Papa,Myriam Heiman +16 more
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.