M
Myriam Heiman
Researcher at Picower Institute for Learning and Memory
Publications - 51
Citations - 6125
Myriam Heiman is an academic researcher from Picower Institute for Learning and Memory. The author has contributed to research in topics: Medicine & Medium spiny neuron. The author has an hindex of 22, co-authored 43 publications receiving 4734 citations. Previous affiliations of Myriam Heiman include Vassar College & Massachusetts Institute of Technology.
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Journal ArticleDOI
A Translational Profiling Approach for the Molecular Characterization of CNS Cell Types
Myriam Heiman,Anne Schaefer,Shiaoching Gong,Jayms D. Peterson,Michelle Day,Keri E. Ramsey,Mayte Suárez-Fariñas,Cordelia Schwarz,Dietrich A. Stephan,D. James Surmeier,Paul Greengard,Nathaniel Heintz,Nathaniel Heintz +12 more
TL;DR: This genetically targeted translating ribosome affinity purification (TRAP) methodology is a generalizable method useful for the identification of molecular changes in any genetically defined cell type in response to genetic alterations, disease, or pharmacological perturbations.
Journal ArticleDOI
Application of a Translational Profiling Approach for the Comparative Analysis of CNS Cell Types
Joseph P. Doyle,Joseph D. Dougherty,Myriam Heiman,Eric F. Schmidt,Tanya R. Stevens,Guojun Ma,Sujata Bupp,Prerana Shrestha,Rajiv D. Shah,Martin L. Doughty,Shiaoching Gong,Shiaoching Gong,Paul Greengard,Nathaniel Heintz,Nathaniel Heintz +14 more
TL;DR: In this article, translational profiles for 24 central nervous system (CNS) cell populations and identified known cell-specific and enriched transcripts for each population were presented. But, the translational profile for each cell population was not used in whole-tissue microarray studies.
Journal ArticleDOI
Normal aging induces A1-like astrocyte reactivity
Laura E. Clarke,Shane A. Liddelow,Chandrani Chakraborty,Alexandra E. Münch,Myriam Heiman,Ben A. Barres +5 more
TL;DR: The aging-induced up-regulation of reactive astrocytes genes was significantly reduced in mice lacking the microglial-secreted cytokines known to induce A1 reactiveAstrocyte formation, indicating that microglia promote astroCyte activation in aging.
Journal ArticleDOI
IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
Alana G. Lerner,John-Paul Upton,P. V.K. Praveen,Rajarshi Ghosh,Yoshimi Nakagawa,Aeid Igbaria,Sarah Shen,Vinh Son Nguyen,Bradley J. Backes,Myriam Heiman,Myriam Heiman,Myriam Heiman,Nathaniel Heintz,Paul Greengard,Simon T. Hui,Qizhi Tang,Ala Trusina,Scott A. Oakes,Feroz R. Papa +18 more
TL;DR: The IRE1α-TXNIP pathway is used in the terminal UPR to promote sterile inflammation and programmed cell death and may be targeted to develop effective treatments for cell degenerative diseases.
Journal ArticleDOI
Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
TL;DR: This protocol provides a step-by-step guide to implement the TRAP methodology, which takes 2 d to complete once all materials are in hand and bypasses the need for tissue fixation or single-cell suspensions and reports on mRNAs in the entire cell body.