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Sarah Wood
Researcher at University of Bristol
Publications - 16
Citations - 813
Sarah Wood is an academic researcher from University of Bristol. The author has contributed to research in topics: Postsynaptic potential & Neuromuscular junction. The author has an hindex of 8, co-authored 15 publications receiving 769 citations.
Papers
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Journal ArticleDOI
Safety factor at the neuromuscular junction.
Sarah Wood,Clarke R. Slater +1 more
TL;DR: Both acquired autoimmune and inherited congenital diseases of the neuromuscular junction (NMJ) can significantly reduce, or even transiently increase, safety factor.
Journal ArticleDOI
Postsynaptic Abnormalities at the Neuromuscular Junctions of Utrophin-deficient Mice
Anne E. Deconinck,A Potter,Jonathon M. Tinsley,Sarah Wood,Ruth Vater,Carol Young,Laurent Metzinger,Angela Vincent,Clarke R. Slater,Kay E. Davies +9 more
TL;DR: Utrophin is thus not essential for AChR clustering at the NMJ but may act as a component of the postsynaptic cytoskeleton, contributing to the development or maintenance of thePostsynaptic folds.
Journal ArticleDOI
Differential localization of voltage-dependent calcium channel alpha1 subunits at the human and rat neuromuscular junction.
Nicola C. Day,Sarah Wood,Paul G. Ince,Stephen G. Volsen,W. Smith,Clarke R. Slater,Pamela J. Shaw +6 more
TL;DR: Using fluorescence immunocytochemistry, evidence is provided that immunoreactivity to α1A, α1B, and α1E subunits is present at both rat and human adult NMJs and the possibility that all three VDCCs at the NMJ are potential targets for circulating autoantibodies in amyotrophic lateral sclerosis is discussed.
Journal ArticleDOI
Utrophin abundance is reduced at neuromuscular junctions of patients with both inherited and acquired acetylcholine receptor deficiencies
Clarke R. Slater,Carol Young,Sarah Wood,Guy S. Bewick,Lvb Anderson,P. Baxter,Prw Fawcett,Matthew C. Roberts,Leslie Jacobson,Joannes Kuks,Angela Vincent,John Newsom-Davis +11 more
TL;DR: It is concluded that the loss of AChRs in AChR deficiency does not result from the absence of rapsyn or beta-dystroglycan and that reduction of utrophin is probably secondary to the lost ACh Rs, and the possible role of A ChRs and/or utroph in determining the extent of postsynaptic folding is discussed.
Journal ArticleDOI
Infrared thermometry for lesion monitoring in cattle lameness
TL;DR: Infrared thermometry is a non-invasive tool shown to be useful in detecting claw abnormalities in cattle at an individual and herd level and investigate the association with lesion presence over time, suggesting inflammation was present for at least six weeks prior to the behavioural sign of lameness was seen.