S
Sarah Zuber
Researcher at Ludwig Maximilian University of Munich
Publications - 1
Citations - 376
Sarah Zuber is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Caspase 1 & AIM2. The author has an hindex of 1, co-authored 1 publications receiving 225 citations.
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The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.