K
Katharina Ramshorn
Researcher at Ludwig Maximilian University of Munich
Publications - 2
Citations - 385
Katharina Ramshorn is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Caspase 1 & AIM2. The author has an hindex of 1, co-authored 1 publications receiving 225 citations.
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Journal ArticleDOI
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3
Moritz M. Gaidt,Thomas S. Ebert,Dhruv Chauhan,Katharina Ramshorn,Francesca Pinci,Sarah Zuber,Fionan O’Duill,Jonathan L. Schmid-Burgk,Florian Hoss,Raymund Buhmann,Georg Wittmann,Eicke Latz,Eicke Latz,Marion Subklewe,Veit Hornung +14 more
TL;DR: It is shown that AIM2 is dispensable for DNA-mediated inflammasome activation in human myeloid cells, and targeting the cGAS-STING-LCD-NLRP3 pathway will ameliorate pathology in inflammatory conditions that are associated with cytosolic DNA sensing.
Journal ArticleDOI
A purine metabolic checkpoint that prevents autoimmunity and autoinflammation
Svetlana Saveljeva,Gavin W. Sewell,Katharina Ramshorn,M Z Cader,James A. West,Simon Clare,Lea-Maxie Haag,Rodrigo Pereira de Almeida Rodrigues,Lukas Unger,Ana Belén Iglesias-Romero,Lorraine M. Holland,Christophe Bourges,Muhammad N. Md-Ibrahim,James O. Jones,Richard S. Blumberg,James Lee,Nicole C. Kaneider,Trevor D. Lawley,Allan Bradley,Gordon Dougan,Arthur Kaser +20 more
TL;DR: In this paper , a FAMIN-enabled purine metabolon in dendritic cells (DCs) restrains CD4+ and CD8+ T cell priming.