S
Saskia Middeldorp
Researcher at University of Amsterdam
Publications - 297
Citations - 11474
Saskia Middeldorp is an academic researcher from University of Amsterdam. The author has contributed to research in topics: Medicine & Pregnancy. The author has an hindex of 48, co-authored 244 publications receiving 9267 citations. Previous affiliations of Saskia Middeldorp include Academic Medical Center & Radboud University Nijmegen.
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Journal ArticleDOI
Edoxaban versus Warfarin for the Treatment of Symptomatic Venous Thromboembolism
Harry R. Buller,Hervé Decousus,Michael A. Grosso,Saskia Middeldorp,Martin H. Prins,Gary E. Raskob,Sebastian Schellong,Annelise Segers,Minggao Shi,Peter Verhamme,Phil Wells +10 more
TL;DR: Edoxaban administered once daily after initial treatment with heparin was noninferior to high-quality standard therapy and caused significantly less bleeding in a broad spectrum of patients with venous thromboembolism, including those with severe pulmonary embolism.
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VTE, Thrombophilia, Antithrombotic Therapy, and Pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
Shannon M. Bates,Ian A. Greer,Saskia Middeldorp,David L. Veenstra,Anne-Marie Prabulos,Per Olav Vandvik +5 more
TL;DR: In this article, the authors focused on the management of VTE and thrombophilia as well as the use of antithrombotic agents during pregnancy. But they did not consider the risk of pregnancy complications.
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American Society of Hematology 2018 guidelines for management of venous thromboembolism: venous thromboembolism in the context of pregnancy.
Shannon M. Bates,Anita Rajasekhar,Saskia Middeldorp,Claire McLintock,Marc A. Rodger,Marc A. Rodger,Marc A. Rodger,Andra H. James,Sara R. Vazquez,Ian A. Greer,John J. Riva,Meha Bhatt,Nicole Schwab,Danielle Barrett,Andrea LaHaye,Bram Rochwerg +15 more
TL;DR: These evidence-based guidelines of the American Society of Hematology are intended to support patients, clinicians and others in decisions about the prevention and management of pregnancy-associated VTE.
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Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives.
Willem M. Lijfering,Jan-Leendert P. Brouwer,Nic J. G. M. Veeger,Ivan Bank,Michiel Coppens,Saskia Middeldorp,Karly Hamulyák,Martin H. Prins,Harry R. Büller,Jan van der Meer +9 more
TL;DR: Considering its clinical implications, thrombophilia testing should address hereditary deficiencies of antithrombin, protein C, and protein S in patients with first venous thromBosis at young age and/or a strong family history of venousThrombosis.
Journal ArticleDOI
Circulating Nucleosomes and Neutrophil Activation as Risk Factors for Deep Vein Thrombosis
Maurits L. van Montfoort,Femke Stephan,Mandy N. Lauw,Barbara A. Hutten,Gerard van Mierlo,Shabnam Solati,Saskia Middeldorp,Joost C. M. Meijers,Sacha Zeerleder +8 more
TL;DR: The risk of deep vein thrombosis in humans is increased with higher nucleosome and elastase–&agr;1-antitrypsin complex levels, suggesting a dose-dependent relationship among circulating nucleosomes, activated neutrophils, and DVT.