S
Satoko Hayashi
Publications - 3
Citations - 1752
Satoko Hayashi is an academic researcher. The author has contributed to research in topics: RAR-related orphan receptor alpha & Regulation of gene expression. The author has an hindex of 3, co-authored 3 publications receiving 1637 citations.
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Journal ArticleDOI
A transcription factor response element for gene expression during circadian night
Hiroki R. Ueda,Wenbin Chen,Akihito Adachi,Hisanori Wakamatsu,Satoko Hayashi,Tomohiro Takasugi,Mamoru Nagano,Ken-ichi Nakahama,Yutaka Suzuki,Sumio Sugano,Masamitsu Iino,Yasufumi Shigeyoshi,Seiichi Hashimoto +12 more
TL;DR: The role of the Rev-ErbA/ROR response element in gene expression during circadian night is demonstrated, which is in phase with Bmal1 and in antiphase to Per2 oscillations.
Journal ArticleDOI
System-level identification of transcriptional circuits underlying mammalian circadian clocks.
Hiroki R. Ueda,Satoko Hayashi,Wenbin Chen,Motoaki Sano,Masayuki Machida,Yasufumi Shigeyoshi,Masamitsu Iino,Seiichi Hashimoto +7 more
TL;DR: The results indicate that circadian transcriptional circuits are governed by two design principles: regulation of E/E′ boxes and RevErbA/ROR binding elements follows a repressor-precedes-activator pattern, resulting in delayed transcriptional activity, whereas regulation of DBP/E4BP4 binding elements following a repression-antiphasic-to-activators mechanism, which generates high-amplitude transcriptionalactivity.
Journal ArticleDOI
Universality and flexibility in gene expression from bacteria to human
Hiroki R. Ueda,Satoko Hayashi,Shin-ichi Matsuyama,Tetsuya Yomo,Seiichi Hashimoto,Steve A. Kay,John B. Hogenesch,Masamitsu Iino +7 more
TL;DR: It is demonstrated that the gene expression dynamics follows the same and surprisingly simple principle from E. coli to human, and that this "proportional" dynamics or "rich-travel-more" mechanism can regenerate the observed complex and dynamic organization of the transcriptome.