S
Satoshi Sakamoto
Researcher at Tokyo Institute of Technology
Publications - 75
Citations - 1161
Satoshi Sakamoto is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Polymer & Particle. The author has an hindex of 18, co-authored 72 publications receiving 990 citations. Previous affiliations of Satoshi Sakamoto include Tohoku University & Monell Chemical Senses Center.
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Journal ArticleDOI
Preparation of size-controlled (30–100 nm) magnetite nanoparticles for biomedical applications
Kousuke Nishio,Morihito Ikeda,Nobuyuki Gokon,Shingo Tsubouchi,Hiroki Narimatsu,Yusuke Mochizuki,Satoshi Sakamoto,Adarsh Sandhu,M. Abe,Hiroshi Handa +9 more
TL;DR: In this paper, size-controlled magnetite nanoparticles (MNPs) with several dozen nanometers (nm) were synthesized for biomedical applications by oxidizing ferrous hydroxide (Fe(OH) 2 ) with a weak oxidant NaNO 3 in an N 2 -deaerated aqueous NaOH solution at various temperatures below 37°C.
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Development of novel magnetic nano-carriers for high-performance affinity purification.
Kosuke Nishio,Yuka Masaike,Morihito Ikeda,Hiroki Narimatsu,Nobuyuki Gokon,Shingo Tsubouchi,Mamoru Hatakeyama,Satoshi Sakamoto,Naohiro Hanyu,Adarsh Sandhu,Haruma Kawaguchi,Masanori Abe,Hiroshi Handa +12 more
TL;DR: Novel magnetic nano-carriers around 180 nm in diameter showed higher performance compared to commercially available magnetic beads in terms of purification efficiency of target including extent of non-specific binding protein.
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Development and application of high-performance affinity beads: Toward chemical biology and drug discovery
TL;DR: The development of high-performance affinity beads (SG beads and FG beads) that enable one-step affinity purification of drug targets and the elucidation of the mechanism of the action of the drugs are described.
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Structural basis of thalidomide enantiomer binding to cereblon.
Tomoyuki Mori,Takumi Ito,Shujie Liu,Hideki Ando,Satoshi Sakamoto,Yuki Yamaguchi,Etsuko Tokunaga,Norio Shibata,Hiroshi Handa,Toshio Hakoshima +9 more
TL;DR: A mechanism by which thalidomide exerts its effects in a stereospecific manner at the atomic level is established by structural and biochemical studies of (S)- and (R)-enantiomers bound to the primary target of thalidmide, cereblon (CRBN).
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Spongipyran Synthetic Studies. Evolution of a Scalable Total Synthesis of (+)-Spongistatin 1.
Amos B. Smith,Chris Sfouggatakis,Christina A. Risatti,Jeffrey B. Sperry,Wenyu Zhu,Victoria A. Doughty,Takashi Tomioka,Dimitar B. Gotchev,Clay S. Bennett,Satoshi Sakamoto,Onur Atasoylu,Shohei Shirakami,David Bauer,Makoto Takeuchi,Jyunichi Koyanagi,Yasuharu Sakamoto +15 more
TL;DR: The second- and third- generation syntheses, designed with the goal of accessing one gram of (+)-spongistatin 1 (1), maintain both the first-generation strategy for the ABCD aldehyde and final fragment union, while incorporating two more efficient approaches for construction of the EF Wittig salt.