抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Bose-Einstein condensation (BEC) has been observed in a dilute gas of sodium atoms. A Bose-Einstein condensate consists of a macroscopic population of the ground state of the system, and is a coherent state of matter. In an ideal gas, this phase transition is purely quantum-statistical. The study of BEC in weakly interacting systems which can be controlled and observed with precision holds the promise of revealing new macroscopic quantum phenomena that can be understood from first principles.

Bose-Einstein condensation in a gas of sodium atoms

Tables of integrals

There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and bias, the number of other studies on the same question, and, importantly, the ratio of true to no relationships among the relationships probed in each scientific field. In this framework, a research finding is less likely to be true when the studies conducted in a field are smaller; when effect sizes are smaller; when there is a greater number and lesser preselection of tested relationships; where there is greater flexibility in designs, definitions, outcomes, and analytical modes; when there is greater financial and other interest and prejudice; and when more teams are involved in a scientific field in chase of statistical significance. Simulations show that for most study designs and settings, it is more likely for a research claim to be false than true. Moreover, for many current scientific fields, claimed research findings may often be simply accurate measures of the prevailing bias. In this essay, I discuss the implications of these problems for the conduct and interpretation of research.

Why most published research findings are false

The development of wave optics for light brought many new insights into our understanding of physics, driven by fundamental experiments like the ones by Young, Fizeau, Michelson-Morley and others. Quantum mechanics, and especially the de Broglie’s postulate relating the momentum p of a particle to the wave vector k of an matter wave: k = 2 λ = p/ℏ, suggested that wave optical experiments should be also possible with massive particles (see table 1), and over the last 40 years electron and neutron interferometers have demonstrated many fundamental aspects of quantum mechanics [1].

/pdf/optics-and-interferometry-with-atoms-and-molecules-1vnuwajb51.pdf

Optics and interferometry with atoms and molecules

BackgroundBaricitinib is an oral, reversible inhibitor of the Janus kinases JAK1 and JAK2 that may have therapeutic value in patients with rheumatoid arthritis. MethodsWe conducted a 52-week, phase 3, double-blind, placebo- and active-controlled trial in which 1307 patients with active rheumatoid arthritis who were receiving background therapy with methotrexate were randomly assigned to one of three regimens in a 3:3:2 ratio: placebo (switched to baricitinib after 24 weeks), 4 mg of baricitinib once daily, or 40 mg of adalimumab (an anti–tumor necrosis factor α monoclonal antibody) every other week. End-point measures evaluated after adjustment for multiplicity included 20% improvement according to the criteria of the American College of Rheumatology (ACR20 response) (the primary end point), the Disease Activity Score for 28 joints (DAS28), the Health Assessment Questionnaire–Disability Index, and the Simplified Disease Activity Index at week 12, as well as radiographic progression of joint damage as meas...

/pdf/baricitinib-versus-placebo-or-adalimumab-in-rheumatoid-52mbaszlpv.pdf

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

We study the metastability and decay of multiply-charged superflow in a ring-shaped atomic Bose-Einstein condensate. Supercurrent corresponding to a giant vortex with topological charge up to q=10 is phase-imprinted optically and detected both interferometrically and kinematically. We observe q=3 superflow persisting for up to a minute and clearly resolve a cascade of quantised steps in its decay. These stochastic decay events, associated with vortex-induced $2 \pi$ phase slips, correspond to collective jumps of atoms between discrete q values. We demonstrate the ability to detect quantised rotational states with > 99 % fidelity, which allows a detailed quantitative study of time-resolved phase-slip dynamics. We find that the supercurrent decays rapidly if the superflow speed exceeds a critical velocity in good agreement with numerical simulations, and we also observe rare stochastic phase slips for superflow speeds below the critical velocity.

/pdf/quantized-supercurrent-decay-in-an-annular-bose-einstein-2y1gxu4b3a.pdf

Quantized supercurrent decay in an annular Bose-Einstein condensate

We create and study persistent currents in a toroidal two-component Bose gas, consisting of 87Rb atoms in two different spin states. For a large spin-population imbalance we observe supercurrents persisting for over two minutes. However, we find that the supercurrent is unstable for spin polarization below a well-defined critical value. We also investigate the role of phase coherence between the two spin components and show that only the magnitude of the spin-polarization vector, rather than its orientation in spin space, is relevant for supercurrent stability.

http://www-amop.phy.cam.ac.uk/amop-zh/Publications/PersistentCurrentsInSpinorCondensates.pdf

Persistent currents in spinor condensates.

Background and Purpose— The presence of new ischemic brain infarcts, detected by diffusion-weighted magnetic resonance imaging (DW-MRI), have been reported in considerable number of patients after cardiac surgery. We sought to determine the role of proximal thoracic aortic atheroma in predicting embolic events and new ischemic brain lesions in patients undergoing conventional coronary revascularization surgery. Methods— Transesophageal echocardiography and epiaortic scanning was performed to assess the severity of aortic atherosclerosis in the ascending aorta and the aortic arch. Patients were allocated to either low-risk group, (intimal thickness ≤2mm), or high-risk group (intimal thickness >2mm). Transcranial Doppler was used to monitor the middle cerebral artery. DW-MRI was performed 3–7 days after surgery. The NEECHAM Confusion Scale was used for assessment and monitoring patient consciousness level. Results— Patients in the high-risk group were considerably older; 71±6 (n=38) versus 67±6 (n=72) years...

Mild to moderate atheromatous disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery.

Background:This propensity score–matched cohort study evaluates the effect of anesthetic technique on a 30-day mortality after total hip or knee arthroplasty.Methods:All patients who had hip or knee arthroplasty between January 1, 2003, and December 31, 2014, were evaluated. The principal exposure w

Scott Beattie

Papers

Baricitinib versus Placebo or Adalimumab in Rheumatoid Arthritis

Quantized supercurrent decay in an annular Bose-Einstein condensate

Persistent currents in spinor condensates.

Mild to moderate atheromatous disease of the thoracic aorta and new ischemic brain lesions after conventional coronary artery bypass graft surgery.

Anesthesia Technique and Mortality after Total Hip or Knee Arthroplasty: A Retrospective, Propensity Score-matched Cohort Study.