S
Scott P. Runyon
Researcher at Research Triangle Park
Publications - 69
Citations - 1039
Scott P. Runyon is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Opioid receptor. The author has an hindex of 20, co-authored 67 publications receiving 883 citations. Previous affiliations of Scott P. Runyon include RTI International & University of Minnesota.
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Journal ArticleDOI
Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.
Marco Pravetoni,Daniel E. Keyler,Ramakrishna R. Pidaparthi,Frank I. Carroll,Scott P. Runyon,Michael P. Murtaugh,C. A. Earley,Paul R. Pentel +7 more
TL;DR: The data show that it is possible to design multiple immunogens from a small molecule such as nicotine which elicit independent immune responses and could be applicable to other addiction vaccines or small molecule targets as well.
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Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse
Michael D. Raleigh,Samantha J. Peterson,Megan Laudenbach,Federico Baruffaldi,Frank I. Carroll,Sandra D. Comer,Hernán A. Navarro,Tiffany L. Langston,Scott P. Runyon,S. Winston,Marco Pravetoni,Paul R. Pentel +11 more
TL;DR: In vitro receptor binding assays showed that antibody-bound oxycodone does not activate mu opioid receptors, which supports further study of OXY-dKLH as a potential treatment for oxy codone abuse and suggests that vaccination might also reduce the severity of oxycod one overdose.
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Hydrolytic instability of the important orexin 1 receptor antagonist SB-334867: possible confounding effects on in vivo and in vitro studies.
Charles J. McElhinny,Anita H. Lewin,S. Wayne Mascarella,Scott P. Runyon,Lawrence E. Brieaddy,F. Ivy Carroll +5 more
TL;DR: It is suggested that studies using SB-334867 (and any other 2-methylbenzoxazole-containing compound) should be performed with great care to avoid the confounding effects of the rapid hydrolytic decomposition of this susceptible structure.
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Regulation of the Apelinergic System and Its Potential in Cardiovascular Disease: Peptides and Small Molecules as Tools for Discovery.
TL;DR: Development of metabolically stable ligands of apelin receptor and their effects in various models over the coming years will hopefully lead to establishment of this receptor as a validated target for cardiovascular indications.
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Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins.
Federico Baruffaldi,April Huseby Kelcher,Megan Laudenbach,Valeria Gradinati,Ajinkya Limkar,Michaela J. Roslawski,Angela K. Birnbaum,Andrew Lees,Carla Hassler,Scott P. Runyon,Marco Pravetoni +10 more
TL;DR: Heroin vaccines formulated with either EcoCRM or KLH were equally effective in reducing heroin-induced antinociception and distribution to the brain of heroin and its metabolites in mice and identifies vaccine candidates and vaccine components for further development.