S
Scott P. Runyon
Researcher at Research Triangle Park
Publications - 69
Citations - 1039
Scott P. Runyon is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Agonist & Opioid receptor. The author has an hindex of 20, co-authored 67 publications receiving 883 citations. Previous affiliations of Scott P. Runyon include RTI International & University of Minnesota.
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Journal ArticleDOI
Design, synthesis, and pharmacological evaluation of JDTic analogs to examine the significance of replacement of the 3-hydroxyphenyl group with pyridine or thiophene bioisosteres.
Chad M. Kormos,Moses G. Gichinga,Scott P. Runyon,James B. Thomas,S. Wayne Mascarella,Ann M. Decker,Hernán A. Navarro,F. Ivy Carroll +7 more
TL;DR: Of the JDTic analogs, (3R)-7-hydroxy-N-(1S)-2-methyl-[4-methyl-4-pyridine-3-yl-carboxamide (3b)) had the best overall binding potency and selectivity in a [(35)S]GTPγS functional assay, and Calculated physiochemical properties for 3b suggest that it will cross the blood-brain barrier.
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Efficacy and Selectivity of Monovalent and Bivalent Vaccination Strategies to Protect against Exposure to Carfentanil, Fentanyl, and Their Mixtures in Rats.
Bethany Crouse,Mariah M. Wu,Valeria Gradinati,Andrew J. Kassick,Daihyun Song,Rajwana Jahan,Saadyah Averick,Scott P. Runyon,Sandra D. Comer,Marco Pravetoni +9 more
TL;DR: Preclinical data support the development of vaccines as a viable strategy to prevent toxicity from exposure to excessive doses of carfentanil, fentanyl, or their mixtures.
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Identification of N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine (NTRC-808), a novel nonpeptide chemotype selective for the neurotensin receptor type 2.
James B. Thomas,Angela M. Giddings,Srinivas Olepu,Robert W. Wiethe,Danni L. Harris,Sanju Narayanan,Keith R. Warner,Philippe Sarret,Jean-Michel Longpré,Scott P. Runyon,Brian P. Gilmour +10 more
TL;DR: Modification of the screening hit to include structural features known to be recognized by NTS1 and NTS2, led to the identification of the novel NTS2 selective nonpeptide, N-{[6-chloro-4-(2,6-dimethoxyphenyl)quinazolin-2-yl]carbonyl}-l-leucine.
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Simple Tetrahydroisoquinolines Are Potent and Selective Kappa Opioid Receptor Antagonists.
Chad M. Kormos,Pauline W. Ondachi,Scott P. Runyon,James B. Thomas,S. Wayne Mascarella,Ann M. Decker,Hernán A. Navarro,F. Ivy Carroll +7 more
TL;DR: In order to determine if the 3-hydroxyphenyl and/or the piperidine amino groups are required for obtaining the pure opioid antagonists, (3R)-7-hydroxy-N-[(1S)-2-methyl-1-(piperidine-1-ylmethyl)propyl]-1,2,3,4-tetrahydroiosquinoline-3-carboxamide was synthesized and evaluated.
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Acute and chronic effects of a contraceptive compound RTI-4587-073(l) on testicular histology and endocrine function in miniature horse stallions.
Malgorzata A. Pozor,G. L. Zambrano,Janet F. Roser,Rex A. Hess,Scott P. Runyon,E. E. Runcan,Brian F. Thomas,D Dymock,Margo L. Macpherson,M.H.T. Troedsson,Audrey A. Kelleman +10 more
TL;DR: It is concluded that RTI-4587-073(l) has significant but transient effects on Leydig cell function in stallions and causes acute sloughing of immature germ cells from the seminiferous tubules.