S
Sean Carlin
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 83
Citations - 3661
Sean Carlin is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Tumor hypoxia & Cancer. The author has an hindex of 34, co-authored 77 publications receiving 3185 citations. Previous affiliations of Sean Carlin include French Institute of Health and Medical Research & University of Glasgow.
Papers
More filters
Journal ArticleDOI
Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo
Sriram Venneti,Mark Dunphy,Hanwen Zhang,Kenneth L. Pitter,Patrick Zanzonico,Carl Campos,Sean Carlin,Gaspare La Rocca,Serge K. Lyashchenko,Karl Ploessl,Daniel Rohle,Antonio Omuro,Justin R. Cross,Cameron Brennan,Wolfgang A. Weber,Eric C. Holland,Ingo K. Mellinghoff,Hank F. Kung,Jason S. Lewis,Craig B. Thompson +19 more
TL;DR: It is demonstrated that PET imaging in vivo with the glutamine analog 4-18F-(2S,4R)-fluoroglutamine (18F-FGln) shows high uptake in gliomas but low background brain uptake, facilitating clear tumor delineation.
Journal ArticleDOI
A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry
Brian M. Zeglis,Kuntal K. Sevak,Thomas Reiner,Priya Mohindra,Sean Carlin,Pat Zanzonico,Ralph Weissleder,Jason S. Lewis +7 more
TL;DR: The development of a methodology for pretargeted PET imaging based on the bioorthogonal Diels–Alder click reaction between tetrazine and transcyclooctene and the high quality of the images produced by this pretargeting approach is reported, marking this system as a strong candidate for clinical translation.
Journal ArticleDOI
Dependence of FDG uptake on tumor microenvironment
Andrei Pugachev,Shutian Ruan,Sean Carlin,Steven M. Larson,Jose Campa,C. Clifton Ling,John L. Humm +6 more
TL;DR: In this article, the authors investigated the factors affecting the 18 F-fluorodeoxyglucose (18 F-FDG) uptake in tumors at a microscopic level, by correlating it with tumor hypoxia, cellular proliferation, and blood perfusion.
Journal ArticleDOI
Magnitude of Enhanced Permeability and Retention Effect in Tumors with Different Phenotypes: 89Zr-Albumin as a Model System
TL;DR: The influence of different tumor phenotypes on the EPR effect is investigated, hypothesizing that a baseline level of uptake must be exceeded to visualize high and specific uptake of a targeted macromolecular radiotracer.
Journal ArticleDOI
Noninvasive Multimodality Imaging of the Tumor Microenvironment: Registered Dynamic Magnetic Resonance Imaging and Positron Emission Tomography Studies of a Preclinical Tumor Model of Tumor Hypoxia
HyungJoon Cho,Ellen Ackerstaff,Sean Carlin,Mihaela E. Lupu,Ya Wang,Asif Rizwan,Joseph A. O'Donoghue,C. Clifton Ling,John L. Humm,Pat Zanzonico,Jason A. Koutcher +10 more
TL;DR: The relationships between DCE-MRI and hematoxylin/eosin slices and between (18)F-Fmiso PET and pimonidazole slices confirm the validity of MRI/PET measurements to image the tumor microenvironment and to identify regions of tumor necrosis, hypoxia, and well-perfused tissue.