Carl Campos

TL;DR: It is demonstrated that mutation of a single gene, isocitrate dehydrogenase 1 (IDH1), establishes CIMP by remodelling the methylome, and the epigenomic alterations resulting from mutant IDH1 activate key gene expression programs, characterize G-CIMP-positive proneural glioblastomas but not other gliOBlastomas, and are predictive of improved survival.

TL;DR: The recent discovery of mutations in metabolic enzymes has rekindled interest in harnessing the altered metabolism of cancer cells for cancer therapy, and isocitrate dehydrogenase 1 (IDH1), which is mutated in multiple human cancers, is examined.

TL;DR: It is shown that a unique triple-modality magnetic resonance imaging–photoacoustic imaging–Raman imaging nanoparticle approach can accurately help delineate the margins of brain tumors in living mice both preoperatively and intraoperatively.

TL;DR: It is shown that tumour-derived DNA was detected in CSF from 42 out of 85 patients (49.4%) and was associated with disease burden and adverse outcome and the ability to monitor the evolution of the glioma genome through a minimally invasive technique could advance the clinical development and use of genotype-directed therapies for gliomas.

TL;DR: It is shown that mTORC2 promotes inactivating phosphorylation of class IIa histone deacetylases, which leads to the acetylation of FoxO1 and FoxO3, and this in turn releases c-Myc from a suppressive miR-34c-dependent network.