T
Thomas Reiner
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 175
Citations - 6294
Thomas Reiner is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: In vivo & Cancer. The author has an hindex of 41, co-authored 168 publications receiving 4879 citations. Previous affiliations of Thomas Reiner include Technische Universität München & Kettering University.
Papers
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Journal ArticleDOI
Towards Quantitative Catalytic Lignin Depolymerization
Virginia. M. Roberts,Valentin Stein,Thomas Reiner,Angeliki A. Lemonidou,Angeliki A. Lemonidou,Xuebing Li,Johannes A. Lercher +6 more
TL;DR: Combination of base-catalyzed lignin hydrolysis with addition of boric acid protecting agent shifts the product distribution to lower molecular weight compounds and increases product yields beyond 85%.
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A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels–Alder Click Chemistry
Brian M. Zeglis,Kuntal K. Sevak,Thomas Reiner,Priya Mohindra,Sean Carlin,Pat Zanzonico,Ralph Weissleder,Jason S. Lewis +7 more
TL;DR: The development of a methodology for pretargeted PET imaging based on the bioorthogonal Diels–Alder click reaction between tetrazine and transcyclooctene and the high quality of the images produced by this pretargeting approach is reported, marking this system as a strong candidate for clinical translation.
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Single-cell and subcellular pharmacokinetic imaging allows insight into drug action in vivo
Greg M. Thurber,Katherine S. Yang,Thomas Reiner,Thomas Reiner,Rainer H. Kohler,Peter K. Sorger,Timothy J. Mitchison,Ralph Weissleder +7 more
TL;DR: In vivo single-cell pharmacokinetic imaging of PARP-1 inhibitors is demonstrated and derived modelling is used to validate predictive finite element modelling and suggest that drug inefficiency is likely related to proteomic heterogeneity or insensitivity of cancer cells to DNA-repair inhibition.
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Inhibiting macrophage proliferation suppresses atherosclerotic plaque inflammation
Jun Tang,Mark E. Lobatto,Laurien Hassing,Susanne E. M. van der Staay,Sarian M. van Rijs,Claudia Calcagno,Mounia S. Braza,Samantha Baxter,Francois Fay,Brenda L. Sanchez-Gaytan,Raphaël Duivenvoorden,Hendrik B. Sager,Yaritzy M Astudillo,Wei Leong,Sarayu Ramachandran,Gert Storm,Gert Storm,Carlos Pérez-Medina,Thomas Reiner,David P. Cormode,Gustav J. Strijkers,Erik S.G. Stroes,Filip K. Swirski,Matthias Nahrendorf,Edward A. Fisher,Zahi A. Fayad,Willem J. M. Mulder +26 more
TL;DR: The results demonstrate that pharmacologically inhibiting local macrophage proliferation can effectively treat inflammation in atherosclerosis.
Journal ArticleDOI
PET Imaging of Tumor-Associated Macrophages with 89Zr-Labeled High-Density Lipoprotein Nanoparticles
Carlos Pérez-Medina,Jun Tang,Dalya Abdel-Atti,Brandon Hogstad,Miriam Merad,Edward A. Fisher,Zahi A. Fayad,Jason S. Lewis,Willem J. M. Mulder,Thomas Reiner +9 more
TL;DR: Developing 89Zr-labeled TAM imaging agents based on the natural nanoparticle rHDL could be valuable for noninvasive monitoring of TAM immunology and targeted treatment of malignant growth.