S
Sean E. Lawler
Researcher at Brigham and Women's Hospital
Publications - 157
Citations - 11341
Sean E. Lawler is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Glioma & Tumor microenvironment. The author has an hindex of 44, co-authored 138 publications receiving 9629 citations. Previous affiliations of Sean E. Lawler include Ohio State University & University of California, San Francisco.
Papers
More filters
Journal ArticleDOI
MicroRNAs in cancer: biomarkers, functions and therapy.
TL;DR: The potential applications of microRNAs for the clinical assessment of patient outcome in cancer, as well as in cancer monitoring and therapy are reviewed.
Journal ArticleDOI
microRNA-7 Inhibits the Epidermal Growth Factor Receptor and the Akt Pathway and Is Down-regulated in Glioblastoma
Benjamin Kefas,Jakub Godlewski,Laurey Comeau,Yunqing Li,Roger Abounader,Michael P. Hawkinson,Jeongwu Lee,Howard A. Fine,E. Antonio Chiocca,Sean E. Lawler,Benjamin Purow +10 more
TL;DR: This study establishes miR-7 as a regulator of major cancer pathways and suggests that it has therapeutic potential for glioblastoma.
Journal ArticleDOI
Targeting of the Bmi-1 Oncogene/Stem Cell Renewal Factor by MicroRNA-128 Inhibits Glioma Proliferation and Self-Renewal
Jakub Godlewski,Michał Nowicki,Agnieszka Bronisz,Shante P. Williams,Akihiro Otsuki,Gerard J. Nuovo,Abhik Ray-Chaudhury,Herbert B. Newton,E. Antonio Chiocca,Sean E. Lawler +9 more
TL;DR: This is the first example of specific regulation by a miR of a neural stem cell self-renewal factor, implicating miRs that may normally regulate brain development as important biological and therapeutic targets against the "stem cell-like" characteristics of glioma.
Journal ArticleDOI
Oncolytic Viruses in Cancer Treatment: A Review
TL;DR: Clinical development of OVs is increasingly focused on their immune stimulatory properties, which may work synergistically with immune checkpoint inhibitors and other strategies in the treatment of human cancer, which is an active area of clinical research.
Journal ArticleDOI
Cloning of a type I TGF-beta receptor and its effect on TGF-beta binding to the type II receptor.
Reinhard Ebner,Ruey-Hwa Chen,Lillian Shum,Sean E. Lawler,Thomas F. Zioncheck,Angela Lee,Alfredo R. Lopez,Rik Derynck +7 more
TL;DR: Combinatorial interactions and stoichiometric ratios between the type I and II receptors may determine the extent of TGF-beta binding and the resulting biological activities.