G
Gerard J. Nuovo
Researcher at Ohio State University
Publications - 414
Citations - 32079
Gerard J. Nuovo is an academic researcher from Ohio State University. The author has contributed to research in topics: In situ hybridization & microRNA. The author has an hindex of 89, co-authored 395 publications receiving 29133 citations. Previous affiliations of Gerard J. Nuovo include Stony Brook University & Columbia University.
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Journal ArticleDOI
Complement associated microvascular injury and thrombosis in the pathogenesis of severe COVID-19 infection: A report of five cases.
Cynthia M. Magro,J. Justin Mulvey,David A. Berlin,Gerard J. Nuovo,Steven P. Salvatore,Joanna Harp,Amelia Baxter-Stoltzfus,Jeffrey Laurence +7 more
TL;DR: At least a subset of sustained, severe COVID-19 may define a type of catastrophic microvascular injury syndrome mediated by activation of complement pathways and an associated procoagulant state, and could suggest targets for specific intervention.
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MicroRNAs bind to Toll-like receptors to induce prometastatic inflammatory response
Muller Fabbri,Alessio Paone,Federica Calore,Roberta Galli,Eugenio Gaudio,Ramasamy Santhanam,Francesca Lovat,Paolo Fadda,Charlene Mao,Gerard J. Nuovo,Nicola Zanesi,Melissa Crawford,Gulcin Ozer,Dorothee Wernicke,Hansjuerg Alder,Michael A. Caligiuri,Patrick Nana-Sinkam,Danilo Perrotti,Carlo M. Croce +18 more
TL;DR: It is shown that tumor-secreted miR-21 andmiR-29a also can function by another mechanism, by binding as ligands to receptors of the Toll-like receptor (TLR) family, murine TLR7 and human TLR8, in immune cells, triggering a TLR-mediated prometastatic inflammatory response that ultimately may lead to tumor growth and metastasis.
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Expression profiling identifies microRNA signature in pancreatic cancer
Eun Joo Lee,Yuriy Gusev,Jinmai Jiang,Gerard J. Nuovo,Megan R. Lerner,Megan R. Lerner,Wendy L. Frankel,Daniel L. Morgan,Russell G. Postier,Daniel J. Brackett,Daniel J. Brackett,Thomas D. Schmittgen +11 more
TL;DR: A microRNA expression signature has been identified that is associated with pancreatic cancer and Aberrant microRNAs may offer new clues to pancreatic tumorigenesis and may provide diagnostic biomarkers for pancreatic adenocarcinoma.
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CD56bright natural killer cells are present in human lymph nodes and are activated by T cell–derived IL-2: a potential new link between adaptive and innate immunity
Todd A. Fehniger,Megan A. Cooper,Gerard J. Nuovo,Marina Cella,Fabio Facchetti,Marco Colonna,Michael A. Caligiuri +6 more
TL;DR: It is demonstrated that CD56(bright) NK cells are present in human lymph nodes and that endogenous T cell-derived IL-2, acting through the NK high-affinityIL-2 receptor, costimulates CD56 (bright)NK cells to secrete IFN-gamma.
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miR-221&222 regulate TRAIL resistance and enhance tumorigenicity through PTEN and TIMP3 downregulation.
Michela Garofalo,Gianpiero Di Leva,Giulia Romano,Gerard J. Nuovo,Sung-Suk Suh,Apollinaire Ngankeu,Cristian Taccioli,Flavia Pichiorri,Hansjuerg Alder,Paola Secchiero,Pierluigi Gasparini,Arianna Gonelli,Stefan Costinean,Mario Acunzo,Gerolama Condorelli,Carlo M. Croce +15 more
TL;DR: It is reported that miR-221&222 are overexpressed in aggressive non-small cell lung cancer and hepatocarcinoma cells, as compared with less invasive and/or normal lung and liver cells, and it is demonstrated that the MET oncogene is involved in miR+222 activation through the c-Jun transcription factor.