S
Sean W. Kennedy
Researcher at University of Ottawa
Publications - 73
Citations - 3065
Sean W. Kennedy is an academic researcher from University of Ottawa. The author has contributed to research in topics: In ovo & Quail. The author has an hindex of 33, co-authored 73 publications receiving 2786 citations. Previous affiliations of Sean W. Kennedy include Environment Canada & Carleton University.
Papers
More filters
Journal ArticleDOI
Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.
Richard A. Becker,Gerald T. Ankley,Stephen W. Edwards,Sean W. Kennedy,Igor Linkov,Bette Meek,Magdalini Sachana,Helmut Segner,Bart Van Der Burg,Daniel L. Villeneuve,Haruna Watanabe,Tara S. Barton-Maclaren +11 more
TL;DR: A prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described and the applicability of the approach is demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish.
Journal ArticleDOI
In ovo effects of two organophosphate flame retardants, TCPP and TDCPP, on pipping success, development, mRNA expression and thyroid hormone levels in chicken embryos
Amani Farhat,Doug Crump,Suzanne Chiu,Kim L. Williams,Robert J. Letcher,Lewis T. Gauthier,Sean W. Kennedy,Sean W. Kennedy +7 more
TL;DR: The observed phenotypic responses to TCPP and TDCPP exposure may be associated with disruption of the TH axis, which is critical for normal growth and development in birds.
Journal ArticleDOI
Rapid in vitro metabolism of the flame retardant triphenyl phosphate and effects on cytotoxicity and mRNA expression in chicken embryonic hepatocytes.
TL;DR: First reported evidence that across 27 toxicologically relevant genes, DPHP altered more transcripts than its precursor, and that TPHP is also metabolized via a hydroxylation pathway in CEH is reported.
Journal ArticleDOI
Key amino acids in the aryl hydrocarbon receptor predict dioxin sensitivity in avian species.
TL;DR: This work suggests that key amino acids in the AHR1 ligand binding domain are predictive of broad categories of dioxin sensitivity in avian species, and suggests a genetic screen based on these findings could substantially improve risk assessment for dioxIn-like compounds in wild birds.
Journal ArticleDOI
Effects of tris(1,3-dichloro-2-propyl) phosphate and tris(1-chloropropyl) phosphate on cytotoxicity and mRNA expression in primary cultures of avian hepatocytes and neuronal cells.
TL;DR: The results indicate that genes associated with xenobiotic metabolism, the TH pathway, lipid regulation, and growth are vulnerable to TDCPP and TCPP administration in cultured avian hepatocytes.