M
Magdalini Sachana
Researcher at Organisation for Economic Co-operation and Development
Publications - 60
Citations - 1615
Magdalini Sachana is an academic researcher from Organisation for Economic Co-operation and Development. The author has contributed to research in topics: Adverse Outcome Pathway & Medicine. The author has an hindex of 20, co-authored 52 publications receiving 1138 citations. Previous affiliations of Magdalini Sachana include Aristotle University of Thessaloniki & University of Liverpool.
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Journal ArticleDOI
Increasing Scientific Confidence in Adverse Outcome Pathways: Application of Tailored Bradford-Hill Considerations for Evaluating Weight of Evidence.
Richard A. Becker,Gerald T. Ankley,Stephen W. Edwards,Sean W. Kennedy,Igor Linkov,Bette Meek,Magdalini Sachana,Helmut Segner,Bart Van Der Burg,Daniel L. Villeneuve,Haruna Watanabe,Tara S. Barton-Maclaren +11 more
TL;DR: A prototype quantitative model for assessing the WoE of an AOP using tools of multi-criteria decision analysis (MCDA) is described and the applicability of the approach is demonstrated using the case example aromatase inhibition leading to reproductive dysfunction in fish.
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Recommendation on test readiness criteria for new approach methods in toxicology: Exemplified for developmental neurotoxicity
Anna Bal-Price,Helena T. Hogberg,Kevin M. Crofton,Mardas Daneshian,Rex E. FitzGerald,Ellen Fritsche,Tuula Heinonen,Susanne Hougaard Bennekou,Stefanie Klima,Aldert H. Piersma,Magdalini Sachana,Timothy J. Shafer,Andrea Terron,Florianne Monnet-Tschudi,Barbara Viviani,Tanja Waldmann,Remco H.S. Westerink,Martin F. Wilks,Hilda Witters,Marie-Gabrielle Zurich,Marcel Leist +20 more
TL;DR: Suggestions are made on how DNT NAMs may be assembled into an integrated approach to testing and assessment (IATA), and a vision is presented on how further NAM development may be guided by knowledge of signaling pathways necessary for brain development, DNT pathophysiology, and relevant adverse outcome pathways (AOP).
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Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods.
Anna Bal-Price,Francesca Pistollato,Magdalini Sachana,Stephanie K. Bopp,Sharon Munn,Andrew Worth +5 more
TL;DR: This work proposes to incorporate mechanistic knowledge and data derived from in vitro studies to support various regulatory applications including: the identification of potential DNT triggers, initial chemical screening and prioritization, hazard identification and characterization, and assessment of exposure to chemical mixtures.
Journal ArticleDOI
Putative adverse outcome pathways relevant to neurotoxicity
Anna Bal-Price,Kevin M. Crofton,Magdalini Sachana,Timothy J. Shafer,Mamta Behl,Anna Forsby,Alan J. Hargreaves,Brigitte Landesmann,Pamela J. Lein,Jochem Louisse,Florianne Monnet-Tschudi,Alicia Paini,Alexandra Rolaki,Andre Schrattenholz,Cristina Suñol,Christoph van Thriel,Maurice Whelan,Ellen Fritsche +17 more
TL;DR: As a first step in applying the AOP framework to adverse health outcomes associated with exposure to exogenous neurotoxic substances, the EU Reference Laboratory for Alternatives to Animal Testing organized a workshop to identify potential AOPs relevant to neurotoxic and developmental neurotoxic outcomes.
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OECD/EFSA workshop on developmental neurotoxicity (DNT): The use of non-animal test methods for regulatory purposes.
Ellen Fritsche,Kevin M. Crofton,Antonio F. Hernández,Susanne Hougaard Bennekou,Marcel Leist,Anna Bal-Price,Elissa Reaves,Martin F. Wilks,Andrea Terron,Roland Solecki,Magdalini Sachana,Anne Gourmelon +11 more
TL;DR: Current data requirements for in vivo developmental neurotoxicity (DNT) testing are not sufficient to screen and characterize potentially hazardous compounds, and there was agreement on the need to develop a standardized in vitro testing battery to generate additional data on the effects of chemicals on the developing nervous system.