S
Sebastiaan P van Kessel
Researcher at University of Groningen
Publications - 13
Citations - 672
Sebastiaan P van Kessel is an academic researcher from University of Groningen. The author has contributed to research in topics: Levodopa & Parkinson's disease. The author has an hindex of 6, co-authored 11 publications receiving 409 citations.
Papers
More filters
Journal ArticleDOI
Gut bacterial tyrosine decarboxylases restrict levels of levodopa in the treatment of Parkinson’s disease
Sebastiaan P van Kessel,Alexandra K. Frye,Ahmed O. El-Gendy,Maria Castejon,Ali Keshavarzian,Gertjan van Dijk,Sahar El Aidy +6 more
TL;DR: The authors show that bacterial tyrosine decarboxylases (TDC) decrease the levels of levodopa, the primary treatment in Parkinson’s disease, by conversion to dopamine, and suggest TDC as a potential predictive biomarker for treatment.
Journal ArticleDOI
High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae.
Xue Liu,Xue Liu,Clement Gallay,Morten Kjos,Morten Kjos,Arnau Domenech,Jelle Slager,Sebastiaan P van Kessel,Kèvin Knoops,Robin A. Sorg,Jing-Ren Zhang,Jan-Willem Veening,Jan-Willem Veening +12 more
TL;DR: The CRISPRi library provides a valuable tool for characterization of pneumococcal genes and pathways and revealed several promising antibiotic targets.
Journal ArticleDOI
Bacillus subtilis SepF Binds to the C-Terminus of FtsZ
Ewa Król,Sebastiaan P van Kessel,Laura S. van Bezouwen,Neeraj Kumar,Egbert J. Boekema,Dirk-Jan Scheffers +5 more
TL;DR: It is proposed that the secondary and tertiary structure of the FtsZ C-terminus, rather than specific amino acids, are recognized by SepF.
Journal ArticleDOI
Bacterial Metabolites Mirror Altered Gut Microbiota Composition in Patients with Parkinson's Disease
TL;DR: A link between the microbial composition with the observed alterations of bacterial metabolites and their impact on the immune system is established, which could have influential effect in onset, progression and etiology of PD.
Journal ArticleDOI
Gut bacterial deamination of residual levodopa medication for Parkinson's disease
Sebastiaan P van Kessel,Hiltje Riemke de Jong,Simon Laurens Winkel,Sander S. van Leeuwen,Sander S. van Leeuwen,Sieger Adriaan Nelemans,Hjalmar P. Permentier,Ali Keshavarzian,Sahar El Aidy +8 more
TL;DR: Underpins the importance of the metabolic pathways of the gut microbiome involved in drug metabolism not only to preserve drug effectiveness, but also to avoid potential side effects of bacterial breakdown products of the unabsorbed residue of medication.