S
Sebastian Bachmann
Researcher at Charité
Publications - 146
Citations - 7781
Sebastian Bachmann is an academic researcher from Charité. The author has contributed to research in topics: Kidney & Distal convoluted tubule. The author has an hindex of 47, co-authored 146 publications receiving 6963 citations. Previous affiliations of Sebastian Bachmann include Heidelberg University & Hannover Medical School.
Papers
More filters
Journal ArticleDOI
The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension
Ewout J. Hoorn,Stephen B. Walsh,James A. McCormick,Antje Fürstenberg,Chao Ling Yang,Tom Roeschel,Alexander Paliege,Alexander J. Howie,James Conley,Sebastian Bachmann,Robert J. Unwin,David H. Ellison,David H. Ellison +12 more
TL;DR: Findings indicate that tacrolimus-induced chronic hypertension is mediated largely by NCC activation, and suggest that inexpensive and well-tolerated thiazide diuretics may be especially effective in preventing the complications of CNI treatment.
Journal ArticleDOI
The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney.
Hasan Kulaksiz,Franziska Theilig,Sebastian Bachmann,Sven G. Gehrke,Daniel Rost,A Janetzko,Yalcin Cetin,Wolfgang Stremmel +7 more
TL;DR: From the expression of hepcidin in the mammalian kidney, it is concluded that the iron-regulatory hormone is an intrinsic renal peptide which is not only eliminated by the kidney but is also synthesized in the kidney tubular system.
Journal ArticleDOI
Fatal Cardiac Arrhythmia and Long-QT Syndrome in a New Form of Congenital Generalized Lipodystrophy with Muscle Rippling (CGL4) Due to PTRF-CAVIN Mutations
Anna Rajab,Volker Straub,Liza J McCann,Dominik Seelow,Raymonda Varon,Rita Barresi,Anne Schulze,Barbara Lucke,Susanne Lützkendorf,Mohsen Karbasiyan,Sebastian Bachmann,Simone Spuler,Markus Schuelke +12 more
TL;DR: PTRF-CAVIN deficiency presents the phenotypic spectrum caused by a quintessential lack of functional caveolae, and is essential for Caveolae biogenesis.
Journal ArticleDOI
Localization of organic cation transporters OCT1 and OCT2 in rat kidney.
Ulrich Karbach,Jörn Kricke,Friederike Meyer-Wentrup,Valentin Gorboulev,Christopher Volk,Dominique Loffing-Cueni,Brigitte Kaissling,Sebastian Bachmann,Hermann Koepsell +8 more
TL;DR: The data suggest that rO CT1 and rOCT2 are responsible for basolateral cation uptake in the proximal tubule, which represents the first step in cation secretion.
Journal ArticleDOI
Expression of the thiazide-sensitive Na-Cl cotransporter in rat and human kidney
Nicholas Obermüller,Paul Bernstein,Heino Velazquez,Robert F. Reilly,Doris Moser,David H. Ellison,Sebastian Bachmann +6 more
TL;DR: These experiments indicate that the TSC is expressed predominantly by DCT cells in both rat and humans, although expression extends into the CNT cells in humans, and shows that theTSC and Na+/Ca2+ exchanger are coexpressed by a subpopulation of D CT cells near the junction with the C NT.