D
Dominique Loffing-Cueni
Researcher at University of Zurich
Publications - 54
Citations - 3545
Dominique Loffing-Cueni is an academic researcher from University of Zurich. The author has contributed to research in topics: Epithelial sodium channel & Distal convoluted tubule. The author has an hindex of 27, co-authored 50 publications receiving 3165 citations. Previous affiliations of Dominique Loffing-Cueni include Brigham and Women's Hospital & Dartmouth College.
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Journal ArticleDOI
Distribution of transcellular calcium and sodium transport pathways along mouse distal nephron.
Johannes Loffing,Dominique Loffing-Cueni,Victor Valderrabano,L. E. A. Kläusli,Steven C. Hebert,Bernard C. Rossier,Joost G. J. Hoenderop,René J. M. Bindels,Brigitte Kaissling +8 more
TL;DR: DCT2 and CNT are disclosed as major sites for transcellular Ca(2+) transport in the mouse distal nephron, which suggests their mutual interactions in transport regulation.
Journal ArticleDOI
Rapid dephosphorylation of the renal sodium chloride cotransporter in response to oral potassium intake in mice
Mads V. Sorensen,Solveig Grossmann,Marian Roesinger,Nikolay Gresko,Abhijeet Todkar,Gery Barmettler,Urs Ziegler,Alex Odermatt,Dominique Loffing-Cueni,Johannes Loffing +9 more
TL;DR: Downregulation of NCC likely explains the natriuretic effect of an acute oral potassium load in mice and may improve renal potassium excretion by increasing the amount of intraluminal sodium that can be exchanged against potassium in the aldo-sensitive distal nephron.
Journal ArticleDOI
Altered renal distal tubule structure and renal Na(+) and Ca(2+) handling in a mouse model for Gitelman's syndrome.
Johannes Loffing,Volker Vallon,Dominique Loffing-Cueni,Fintan Aregger,Kerstin Richter,Laurence Pietri,May Bloch-Faure,Joost G. J. Hoenderop,Gary E. Shull,Pierre Meneton,Brigitte Kaissling +10 more
TL;DR: Loss of NCC leads to major structural remodeling of the renal distal tubule that goes along with marked changes in glomerular and tubular function, which may explain some of the clinical features of Gitelman's syndrome.
Journal ArticleDOI
Mineralocorticoid versus Glucocorticoid Receptor Occupancy Mediating Aldosterone-Stimulated Sodium Transport in a Novel Renal Cell Line
Hans-Peter Gaeggeler,Elena Gonzalez-Rodriguez,Nicole Fowler Jaeger,Dominique Loffing-Cueni,Rikke Nørregaard,Johannes Loffing,Jean-Daniel Horisberger,Bernard C. Rossier +7 more
TL;DR: Within the physiologic range of aldosterone concentrations, sodium transport is predicted to be controlled by MR occupancy during circadian cycles and by MR and GR occupancy during salt restriction or acute stress.
Journal ArticleDOI
Localization of organic cation transporters OCT1 and OCT2 in rat kidney.
Ulrich Karbach,Jörn Kricke,Friederike Meyer-Wentrup,Valentin Gorboulev,Christopher Volk,Dominique Loffing-Cueni,Brigitte Kaissling,Sebastian Bachmann,Hermann Koepsell +8 more
TL;DR: The data suggest that rO CT1 and rOCT2 are responsible for basolateral cation uptake in the proximal tubule, which represents the first step in cation secretion.