S
Sebastian Canovas
Researcher at University of Murcia
Publications - 44
Citations - 1241
Sebastian Canovas is an academic researcher from University of Murcia. The author has contributed to research in topics: Zona pellucida & DNA methylation. The author has an hindex of 16, co-authored 42 publications receiving 1023 citations. Previous affiliations of Sebastian Canovas include Junta of Andalusia.
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Journal ArticleDOI
Oviduct-specific glycoprotein and heparin modulate sperm–zona pellucida interaction during fertilization and contribute to the control of polyspermy
Pilar Coy,Sebastian Canovas,Irene Mondéjar,Maria Dolores Saavedra,Raquel Romar,Luis Alberto Grullon,Carmen Matás,Manuel Avilés +7 more
TL;DR: It is hypothesized that zona pellucida (ZP) changes during transit of the oocyte along the oviductal ampulla modulate the interaction with spermatozoa, contributing to the regulation of polyspermy.
Journal ArticleDOI
DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids
Sebastian Canovas,Elena Ivanova,Raquel Romar,Soledad García-Martínez,Cristina Soriano-Úbeda,Francisco A. García-Vázquez,Heba Saadeh,Simon Andrews,Gavin Kelsey,Gavin Kelsey,Pilar Coy +10 more
TL;DR: RNA-Seq and DNA methylation analyses showed that Natur-IVF embryos have expression and methylation patterns closer to in vivo blastocysts, and Genes involved in reprogramming, imprinting and development were affected by culture, with fewer aberrations in Natures IVF embryos.
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Cooling and freezing of boar spermatozoa: supplementation of the freezing media with reduced glutathione preserves sperm function.
Joaquín Gadea,Francisco A. García-Vázquez,Carmen Matás,Juan Carlos Gardón,Juan Carlos Gardón,Sebastian Canovas,David Gumbao +6 more
TL;DR: The main findings emerging from this study were that the addition of GSH to the freezing media resulted in an improvement in percent motility and motion parameters of thawed spermatozoa, as measured by both microscopic analysis and computer-assisted semen analysis (CASA).
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Supplementation of the dilution medium after thawing with reduced glutathione improves function and the in vitro fertilizing ability of frozen-thawed bull spermatozoa.
Joaquín Gadea,David Gumbao,Sebastian Canovas,Francisco A. García-Vázquez,Luis Alberto Grullon,Juan Carlos Gardón +5 more
TL;DR: In this paper, the effects of glutathione supplementation of the thawing extender on bull semen parameters to compensate for the decrease in GSH content observed during sperm freezing were evaluated.
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Hardening of the zona pellucida of unfertilized eggs can reduce polyspermic fertilization in the pig and cow
TL;DR: It is proposed that the observed physiological ZP hardening is a mechanism to control polyspermy, differentially affecting various mammalian species and can be imitated by the use of amine-reactive cross-linkers during IVF.