S
Sebastian Doniach
Researcher at Stanford University
Publications - 217
Citations - 20947
Sebastian Doniach is an academic researcher from Stanford University. The author has contributed to research in topics: Small-angle X-ray scattering & Scattering. The author has an hindex of 78, co-authored 217 publications receiving 19797 citations. Previous affiliations of Sebastian Doniach include Genomics Institute of the Novartis Research Foundation & Cornell University.
Papers
More filters
Journal ArticleDOI
How Large is an α-Helix? Studies of the Radii of Gyration of Helical Peptides by Small-angle X-ray Scattering and Molecular Dynamics
TL;DR: Even at the short sequences examined here (≤37 amino acid residues), these α-helical peptides behave as fluctuating semi-broken rods rather than straight cylinders with frayed ends.
Journal ArticleDOI
Transient dimer in the refolding kinetics of cytochrome c characterized by small-angle X-ray scattering.
Daniel J. Segel,David Eliezer,Vladimir N. Uversky,Anthony L. Fink,Keith O. Hodgson,Sebastian Doniach +5 more
TL;DR: Final protein and denaturant concentrations were varied in the refolding kinetics, and the singular value decomposition (SVD) method was employed to characterize the associated state, which was determined to be a dimer, with properties consistent with a molten globule.
Journal ArticleDOI
Dissecting electrostatic screening, specific ion binding, and ligand binding in an energetic model for glycine riboswitch folding
TL;DR: A case study of how ion-dependent electrostatic relaxation, specific ion binding, and ligand binding can be coupled to shape the energetic landscape of a riboswitch and can begin to be quantitatively dissected is provided.
Journal ArticleDOI
Do conformational biases of simple helical junctions influence RNA folding stability and specificity
TL;DR: Junction topology provides a fundamental strategy for transcending the limitations imposed by the low information content of RNA primary sequence and defining the accessible conformational space, thereby stabilizing desired structures and assisting in discriminating against misfolded structures.
Journal ArticleDOI
Toward the mechanism of dynamical couplings and translocation in hepatitis C virus NS3 helicase using elastic network model
TL;DR: The correlation analysis identifies a network of hot‐spot residues that dynamically couple the ATP‐binding site and the polynucleotide‐binding sites in NS3 helicase that are found to be dominated by the lowest frequency mode solved from the ENM.