Sebastian Heck

TL;DR: Although the antiinflammatory effects of gold nanoparticles might be of therapeutic benefit, systemic uptake and consequent adverse effects must be considered when designing and testing nanoparticle-based asthma therapies.

TL;DR: Asthmatics in Germany with bronchial asthma are highly likely to suffer from co-existing diseases and their treatments should reflect this, and based on the calculated chances of manifestation for these comorbidities, also metabolic, cardiovascular, and mental disorders should be taken into consideration.

TL;DR: A review of potential therapeutic approaches that are likely to show clinical efficacy in the near future, focusing on biologicals as promising novel therapies for severe asthma is presented in this article, with a focus on the development of novel biologicals that target a diverse array of phenotype-specific molecular targets in patients suffering from severe asthma.

TL;DR: The present findings suggest that DCs may migrate from outside into the ganglia to interact with sensory neurons enhancing or protecting the allergic airway inflammation.

TL;DR: This study revealed for the first time an increase of MC-nerve association and neuropeptide receptor expression on MCs during AR as well as nerve fibres containing receptors for MCs.