S
Sébastien Bonnet
Researcher at Laval University
Publications - 195
Citations - 12429
Sébastien Bonnet is an academic researcher from Laval University. The author has contributed to research in topics: Pulmonary hypertension & Medicine. The author has an hindex of 54, co-authored 171 publications receiving 10254 citations. Previous affiliations of Sébastien Bonnet include University of Alberta & French Institute of Health and Medical Research.
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Journal ArticleDOI
Apolipoprotein A-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p
Salil Sharma,Soban Umar,François Potus,Andrea Iorga,Gabriel Wong,David Meriwether,Sandra Breuils-Bonnet,Denise Mai,Kaveh Navab,David J. Ross,Mohamad Navab,Steeve Provencher,Alan M. Fogelman,Sébastien Bonnet,Srinivasa T. Reddy,Mansoureh Eghbali +15 more
TL;DR: These studies establish the importance of microRNAs as downstream effectors of an apolipoprotein A-I mimetic peptide in the rescue of pulmonary arterial hypertension and suggest that treatment with Apolipop Protein A- I mimetic Peptide or miR193 may have therapeutic value.
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HDAC6: A Novel Histone Deacetylase Implicated in Pulmonary Arterial Hypertension
Olivier Boucherat,Sophie Chabot,Roxane Paulin,Isabelle Trinh,Alice Bourgeois,François Potus,Marie-Claude Lampron,Caroline Lambert,Sandra Breuils-Bonnet,Valérie Nadeau,Renée Paradis,Elena A. Goncharova,Steeve Provencher,Sébastien Bonnet +13 more
TL;DR: For the first time, pharmacological inhibition of HDAC6 improved established PAH in two experimental models and can be safely given in combination with currently approved PAH therapies.
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Translational Advances in the Field of Pulmonary Hypertension.Translating MicroRNA Biology in Pulmonary Hypertension. It Will Take More Than “miR” Words
TL;DR: Translating MicroRNA Biology in Pulmonary Hypertension It will take more than “miR” Words to be translated into English, and the translated words will need to be modified to reflect the language barrier.
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Mitochondrial HSP90 Accumulation Promotes Vascular Remodeling in Pulmonary Arterial Hypertension.
Olivier Boucherat,Thibaut Peterlini,Alice Bourgeois,Valérie Nadeau,Sandra Breuils-Bonnet,Stéphanie Boilet-Molez,François Potus,Jolyane Meloche,Sophie Chabot,Caroline Lambert,Eve Tremblay,Young Chan Chae,Dario C. Altieri,Gopinath Sutendra,Evangelos D. Michelakis,Roxane Paulin,Steeve Provencher,Sébastien Bonnet +17 more
TL;DR: The data show for the first time that accumulation of mtHSP90 is a feature of PAH‐PASMCs and a key regulator of mitochondrial homeostasis contributing to vascular remodeling in PAH.
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RAGE-Dependent Activation of the Oncoprotein Pim1 Plays a Critical Role in Systemic Vascular Remodeling Processes
Jolyane Meloche,Roxane Paulin,Audrey Courboulin,Caroline Lambert,Marjorie Barrier,Pierre Bonnet,Malik Bisserier,M. Roy,Mark A. Sussman,Mohsen Agharazii,Sébastien Bonnet +10 more
TL;DR: In vivo, RAGE inhibition decreases STAT3/Pim1/NFAT activation, reversing vascular remodeling in the rat carotid artery-injured model and Molecules aimed to inhibit RAGE could be of a great therapeutic interest for the treatment of VRD.